Nerve terminal currents at lizard neuromuscular junction (Lindgren, Moore 1989)

 Download zip file   Auto-launch 
Help downloading and running models
Loose patch clamp measurement of presynaptic ionic currents at lizard neuromuscular junction compared with computer simulations.
1 . Lindgren CA, Moore JW (1989) Identification of ionic currents at presynaptic nerve endings of the lizard. J Physiol 414:201-22 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuromuscular Junction;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s): I Na,t; I K;
Gap Junctions:
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Action Potentials;
Implementer(s): Hines, Michael [Michael.Hines at];
Search NeuronDB for information about:  I Na,t; I K;
Lindgren and Moore. (1989) Identification of ionic currents at
presynaptic nerve terminal of the lizard.
J. Physiol. 414: 201-222

Experimental observations of ionic currents localized in the presynaptic
terminal region were made with a focal loose-patch clamp.  In addition
to finding Hodgkin-Huxley (HH) type sodium and potassium currents an L
type calcium channel and a calcium-activated potassium channel were

Computer simulations matching the invasion of the action potential
(figure 2) and the major current patterns (figure 1) were able to be
generated, using only the Na and K channels of HH

The NEURON implementation of this model was prepared by Michael Hines. 
Questions about details of this implementation should be addressed to
him at 

Loading data, please wait...