Effect of riluzole on action potential in cultured human skeletal muscle cells (Wang YJ et al. 2008)

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Accession:105528
Simulation studies also unraveled that both decreased conductance of I(Na) and increased conductance of I(K(Ca)) utilized to mimic riluzole actions in skeletal muscle cells could combine to decrease the amplitude of action potentials and increase the repolarization of action potentials.
Reference:
1 . Wang YJ, Lin MW, Lin AA, Wu SN (2008) Riluzole-induced block of voltage-gated Na(+) current and activation of BK(Ca) channels in cultured differentiated human skeletal muscle cells. Life Sci 82:11-20 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Skeletal muscle cell;
Channel(s): I K,Ca; I Sodium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: XPP;
Model Concept(s): Action Potentials;
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Wang, Ya-Jean ;
Search NeuronDB for information about:  I K,Ca; I Sodium;
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SkM_AP
readme.html
SkM_AP.JPG
SkM_AP_KCa.ode
                            
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