CA1 pyramidal neuron: calculation of MRI signals (Cassara et al. 2008)

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Accession:106551
NEURON mod files from the paper: Cassarà AM, Hagberg GE, Bianciardi M, Migliore M, Maraviglia B. Realistic simulations of neuronal activity: A contribution to the debate on direct detection of neuronal currents by MRI. Neuroimage. 39:87-106 (2008). In this paper, we use a detailed calculation of the magnetic field produced by the neuronal currents propagating over a hippocampal CA1 pyramidal neuron placed inside a cubic MR voxel of length 1.2 mm to estimate the Magnetic Resonance signal.
References:
1 . Cassara AM, Hagberg GE, Bianciardi M, Migliore M, Maraviglia B (2008) Realistic simulations of neuronal activity: A contribution to the debate on direct detection of neuronal currents by MRI. Neuroimage 39:87-106 [PubMed]
2 . Cassara AM, Maraviglia B (2008) Microscopic investigation the resonant mechanism for the implementation of nc-MRI at Ultra-Low Field NeuroImage 41(4):1228-41
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I A; I K; I h;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites; Detailed Neuronal Models; Extracellular Fields;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA; I Na,t; I A; I K; I h; Glutamate;
/
nc-mri
readme.txt
distr.mod *
h.mod *
kadist.mod *
kaprox.mod *
kdrca1.mod *
na3n.mod *
naxn.mod *
netstims.mod *
geoc8076.hoc *
mosinit.hoc
Neuron1.hoc
synapses.hoc
                            
NEURON mod files from the paper:

Cassarà AM, Hagberg GE, Bianciardi M, Migliore M, Maraviglia B.
Realistic simulations of neuronal activity: A contribution to the
debate on direct detection of neuronal currents by MRI.
Neuroimage. 39:87-106 (2008).

In this paper, we use a detailed calculation of the magnetic field
produced by the neuronal currents propagating over a hippocampal CA1
pyramidal neuron placed inside a cubic MR voxel of length 1.2 mm to
estimate the Magnetic Resonance signal.

The simulation Neuron1.hoc reproduces traces similar to those in Fig.7
(top two panels) and in Fig.8a of the paper.

Under unix systems:
to compile the mod files use the command 
nrnivmodl 
and run the simulation hoc file with the command 
nrngui Neuron1.hoc

Under Windows systems:
to compile the mod files use the "mknrndll" command.
A double click on the simulation file
Neuron1.hoc 
will open the simulation window.

Questions on how to use this model
should be directed to antonio.cassara@roma1.infn.it

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