Calcium spikes in basal dendrites (Kampa and Stuart 2006)

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Accession:108458
This model was published in Kampa & Stuart (2006) J Neurosci 26(28):7424-32. The simulation creates two plots showing voltage and calcium changes in basal dendrites of layer 5 pyramidal neurons during action potential backpropagation. created by B. Kampa (2006)
Reference:
1 . Kampa BM, Stuart GJ (2006) Calcium spikes in basal dendrites of layer 5 pyramidal neurons during action potential bursts. J Neurosci 26:7424-32 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex U1 L5B pyramidal pyramidal tract GLU cell;
Channel(s): I L high threshold; I T low threshold; I A; I Sodium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Action Potentials; Synaptic Integration; Calcium dynamics;
Implementer(s): Kampa, Bjorn M [Bjoern.Kampa at anu.edu.au];
Search NeuronDB for information about:  Neocortex U1 L5B pyramidal pyramidal tract GLU cell; I L high threshold; I T low threshold; I A; I Sodium; I Potassium;
// Creates Checkbox panel as User Interface to choose number of APs etc
//
// by B.Kampa 2006

proc MakePanel() {
	// this panel creates controls for basal dendrites
	AP1_toq=0
	AP2_toq=0
	AP3_toq=0
	AP4_toq=0
	AP5_toq=0
	IKa_toq=0
	TTX_toq=0
	forsec basal_dendrites {new_it = gbar_it/spinescale} 
	forsec basal_dendrites {new_ca = gbar_ca/spinescale} 
xpanel("BAPcontrol")
	xlabel("AP stimulation")
     	xcheckbox("1 AP",&AP1_toq,"set_stim()")
     	xcheckbox("2 AP",&AP2_toq,"set_stim()")
     	xcheckbox("3 AP",&AP3_toq,"set_stim()")
     	xcheckbox("4 AP",&AP4_toq,"set_stim()")
     	xcheckbox("5 AP",&AP5_toq,"set_stim()")
	xlabel("basal dendritic mechanisms")
	xcheckbox("4-AP application",&IKa_toq,"set_IKa()")
	xcheckbox("TTX puff",&TTX_toq,"set_INa()")
	xlabel("Ca channels in basal dendrites")
	xvalue("T-type","new_it",1,"set_it()")
	xvalue("HVA-type","new_ca",1,"set_ca()")
xpanel()
}

proc set_stim() {
	if(AP1_toq) {
		Step[0].amp=4
		print "1 AP"
	} else{Step[0].amp=0}
	if(AP2_toq) {
		Step[1].amp=4
		print "2 AP"
	}else{Step[1].amp=0}
	if(AP3_toq) {
		Step[2].amp=4
		print "3 AP"
	}else{Step[2].amp=0}
	if(AP4_toq) {
		Step[3].amp=4
		print "4 AP"
	}else{Step[3].amp=0}
	if(AP5_toq) {
		Step[4].amp=4
		print "5 AP"
	}else{Step[4].amp=0}
}

proc set_IKa() {
	if(IKa_toq) {
		// 4-AP application
		forsec dendritic_only gbar_ka=0
		print "4-AP application"
		}else{forsec dendritic_only gbar_ka = gka_dend
			forsec basal_dendrites gbar_ka=gka_basal
		}
}

proc set_INa() {
	if(TTX_toq) {
		// TTX puff
		dend1[1045] distance()
		forsec basal_dendrites for(x) if(distance(x)<30) gbar_na=0
		print "TTX puff"
		}else{forsec basal_dendrites gbar_na=gna_dend	}
}

proc set_it() {
	forsec basal_dendrites gbar_it = new_it*spinescale
}

proc set_ca() {
	forsec basal_dendrites gbar_ca = new_ca*spinescale
}

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