Calcium spikes in basal dendrites (Kampa and Stuart 2006)

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Accession:108458
This model was published in Kampa & Stuart (2006) J Neurosci 26(28):7424-32. The simulation creates two plots showing voltage and calcium changes in basal dendrites of layer 5 pyramidal neurons during action potential backpropagation. created by B. Kampa (2006)
Reference:
1 . Kampa BM, Stuart GJ (2006) Calcium spikes in basal dendrites of layer 5 pyramidal neurons during action potential bursts. J Neurosci 26:7424-32 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex U1 L5B pyramidal pyramidal tract GLU cell;
Channel(s): I L high threshold; I T low threshold; I A; I Sodium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Active Dendrites; Action Potentials; Synaptic Integration; Calcium dynamics;
Implementer(s): Kampa, Bjorn M [Bjoern.Kampa at anu.edu.au];
Search NeuronDB for information about:  Neocortex U1 L5B pyramidal pyramidal tract GLU cell; I L high threshold; I T low threshold; I A; I Sodium; I Potassium;
// ====================================================================== //
// This hoc file starts simulation of AP backpropagation
// in basal dendrites of cortical layer 5 pyramidal neurons
// as shown in Kampa & Stuart (2006) J Neurosci 26(28):7424 –7432
// 
// File runs a simulation plotting voltage and calcium concentration
// in soma and basal dendrite of Ri18 model neuron from Stuart & Spruston
// (1998). Additional mechanisms were based on those used in a previous model 
// by Schaefer et al. (2003). In addition, a calcium buffer was included 
// similar to Helmchen (1996) with a buffer binding ratio of 20 and a
// clearance rate of 1200 s1 as reported for small dendrites (Sabatini et al.,
// 2002). 
//
// by B.Kampa (2006)
// ======================================================================= //

// program to get geometry and initialise properties of Ri18//

load_file("nrngui.hoc")

xopen("Ri18geo.hoc")
xopen("Ri18organise.hoc")
xopen("Ri18init.hoc")

init_params()
init_spine()
init_cell()
addca()
boostca()
init_basals()

print "Ri18 successfully built\n"

steps_per_ms=10
dt=.1
tstop=1100
access dend1[21]
distance()

		objectvar Step[5]

		Step[0] = new IClamp(0.5)
		Step[0].del= 1010	
		Step[0].dur= 2
		Step[0].amp= 4
		Step[0].i=0

		Step[1] = new IClamp(0.5)
		Step[1].del= 1015	
		Step[1].dur= 2
		Step[1].amp= 4
		Step[1].i=0

		Step[2] = new IClamp(0.5)
		Step[2].del= 1020	
		Step[2].dur= 2
		Step[2].amp= 4
		Step[2].i=0

		Step[3] = new IClamp(0.5)
		Step[3].del= 1025
		Step[3].dur= 2
		Step[3].amp= 4
		Step[3].i=0

		Step[4] = new IClamp(0.5)
		Step[4].del= 1030
		Step[4].dur= 2
		Step[4].amp= 4
		Step[4].i=0

// --------------------------------------------------------------
// replace init procedure to have sufficiently long prepulse
// --------------------------------------------------------------

proc init() {local saveDt, i
  finitialize(v_init)
  fcurrent()
  saveDt = dt
  dt = 10
  for i=0,99 fadvance()
  dt = saveDt
}
	
proc DoIt() {local i, j

  init()
  for i=0,999 {
    for j=0,0.1/dt-1 fadvance()
  }
}

xopen("BAP_Ca.ses")
xopen("BAPcontrol.hoc")
MakePanel()




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