STDP depends on dendritic synapse location (Letzkus et al. 2006)

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Accession:108459
This model was published in Letzkus, Kampa & Stuart (2006) J Neurosci 26(41):10420-9. The simulation creates several plots showing voltage and NMDA current and conductance changes at different apical dendritic locations in layer 5 pyramidal neurons during STDP induction protocols. Created by B. Kampa (2006).
Reference:
1 . Letzkus JJ, Kampa BM, Stuart GJ (2006) Learning rules for spike timing-dependent plasticity depend on dendritic synapse location. J Neurosci 26:10420-9 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell;
Channel(s): I L high threshold; I T low threshold; I A; I M; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Bursting; Active Dendrites; Synaptic Plasticity; Long-term Synaptic Plasticity; Action Potentials; STDP; Calcium dynamics;
Implementer(s): Kampa, Bjorn M [Bjoern.Kampa at anu.edu.au];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; NMDA; I L high threshold; I T low threshold; I A; I M; I K,Ca; I Sodium; I Calcium; I Potassium; Glutamate;
/*
--------------
new organisation of original geometry to make more user friendly
--------------
-the compartment called soma is really part of the axon that was
 reconstructed
-an additional axon is added to this "soma" by ntscable, and therefore
 serves as an extension of the axon
-the reconstructed axon also includes dend1[0] to dend1[13]
-the real soma is dend1[14] to dend1[27]
-dend1[21] is the middle of the soma
-dend1[183] (beginning, ie, 0) is the dendritic recording location

by B.Kampa 2006
*/

access dend1[21]
distance()

objref somaAll,somaCenter,dendritic,dendritic_only,dendritic_distal,axon_only

// Soma
somaAll = new SectionList()
for i=14,27 {
	dend1[i] somaAll.append()
	}
somaCenter = new SectionList()
dend1[21] somaCenter.append()

// Dendrites including soma
dendritic = new SectionList()
// make sure no compartments exceed 20 uM length
forall {
    if(nseg < L/20) { print secname(), " not accurate" nseg=L/20+1 }
    dendritic.append()
  	}
for i=0,13 {
  	dend1[i] dendritic.remove()
	}
forsec "axon" dendritic.remove()
forsec "soma" dendritic.remove()

// dendrites without soma
dendritic_only = new SectionList()
forsec dendritic dendritic_only.append()
for i=14,27 {
  	dend1[i]  dendritic_only.remove()
	}

axon_only = new SectionList()
for i=0,13 {
  	dend1[i] axon_only.append()
	}
forsec "axon" axon_only.append()
forsec "soma" axon_only.append()

// distal dendrites
dendritic_distal = new SectionList()
forsec dendritic_only for(x) if(distance(x) > 600) {dendritic_distal.append()}


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