STDP depends on dendritic synapse location (Letzkus et al. 2006)

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Accession:108459
This model was published in Letzkus, Kampa & Stuart (2006) J Neurosci 26(41):10420-9. The simulation creates several plots showing voltage and NMDA current and conductance changes at different apical dendritic locations in layer 5 pyramidal neurons during STDP induction protocols. Created by B. Kampa (2006).
Reference:
1 . Letzkus JJ, Kampa BM, Stuart GJ (2006) Learning rules for spike timing-dependent plasticity depend on dendritic synapse location. J Neurosci 26:10420-9 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex V1 L6 pyramidal corticothalamic cell;
Channel(s): I L high threshold; I T low threshold; I A; I M; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s): NMDA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Bursting; Active Dendrites; Synaptic Plasticity; Long-term Synaptic Plasticity; Action Potentials; STDP; Calcium dynamics;
Implementer(s): Kampa, Bjorn M [Bjoern.Kampa at anu.edu.au];
Search NeuronDB for information about:  Neocortex V1 L6 pyramidal corticothalamic cell; NMDA; I L high threshold; I T low threshold; I A; I M; I K,Ca; I Sodium; I Calcium; I Potassium; Glutamate;
//----------------------------------------------------------------------------
//  create compartments and insert passive properties
//----------------------------------------------------------------------------

create PRE
PRE {
  diam=10
  L=10
  insert pas
  g_pas=1/5000
  e_pas=v_init
}
//----------------------------------------------------------------------------
//  insert transmitter release mechanisms
//----------------------------------------------------------------------------

PRE {	// insert stim

insert rel	// transmitter release
del_rel = 10
dur_rel = 1	// increase stim.dur to get a burst of presynaptic spikes
amp_rel = 1
}

//----------------------------------------------------------------------------
//  insert nmda receptor mechansisms
//----------------------------------------------------------------------------

objectvar nmda
nmda = new NMDA_Mg()			// create synapse
dend1[425] nmda.loc(0.5)		// assign distal postsynaptic compartment
setpointer nmda.C , PRE.T_rel(0.5)	// assign presynaptic compartment
Erev_NMDA_Mg	= 5			//	(mV)	reversal potential (E_K)
mg_NMDA_Mg		= 1			//	(mM) put in physiol magnesium
nmda.gmax 		= 20000		//	(pS)	maximum conductance
print "NMDA receptor inserted at dendritic location\n"

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