Space clamp problems in neurons with voltage-gated conductances (Bar-Yehuda and Korngreen 2008)

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Accession:110560
" ... using numerical simulations, we show that the distortions of voltage-gated K+ and Ca2+ currents are substantial even in neurons with short dendrites. The simulations also demonstrate that passive cable theory cannot be used to justify voltage-clamping of neurons, due to significant shunting to the reversal potential of the voltage-gated conductance during channel activation. ... "
Reference:
1 . Bar-Yehuda D, Korngreen A (2008) Space clamp problems when voltage clamping neurons expressing voltage-gated conductances. J Neurophysiol 99(3):1127-33 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex V1 pyramidal corticothalamic L6 cell;
Channel(s): I K; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics; Influence of Dendritic Geometry; Detailed Neuronal Models;
Implementer(s): Korngreen, Alon [alon.korngreen at gmail.com];
Search NeuronDB for information about:  Neocortex V1 pyramidal corticothalamic L6 cell; I K; I Calcium;
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SpaceClampDemo
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Bar-Yehuda D, Korngreen A (2008) Space clamp problems when voltage clamping neurons expressing voltage-gated conductances. J Neurophysiol 99(3):1127-33[PubMed]

References and models cited by this paper

References and models that cite this paper

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   Pyramidal Neuron Deep: K+ kinetics (Korngreen, Sakmann 2000) [Model]

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   Correcting space clamp in dendrites (Schaefer et al. 2003 and 2007) [Model]

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   Correcting space clamp in dendrites (Schaefer et al. 2003 and 2007) [Model]

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   Pyramidal neuron coincidence detection tuned by dendritic branching pattern (Schaefer et al 2003) [Model]

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(33 refs)