Cerebellar Golgi cell (Solinas et al. 2007a, 2007b)

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Accession:112685
"... Our results suggest that a complex complement of ionic mechanisms is needed to fine-tune separate aspects of the neuronal response dynamics. Simulations also suggest that the Golgi cell may exploit these mechanisms to obtain a fine regulation of timing of incoming mossy fiber responses and granular layer circuit oscillation and bursting."
References:
1 . Solinas S, Forti L, Cesana E, Mapelli J, De Schutter E, D'Angelo E (2007) Computational reconstruction of pacemaking and intrinsic electroresponsiveness in cerebellar Golgi cells. Front Cell Neurosci 1:2 [PubMed]
2 . Solinas S, Forti L, Cesana E, Mapelli J, De Schutter E, D'Angelo E (2007) Fast-reset of pacemaking and theta-frequency resonance patterns in cerebellar golgi cells: simulations of their impact in vivo. Front Cell Neurosci 1:4 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum golgi cell;
Channel(s): I Na,p; I Na,t; I T low threshold; I A; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium; I h;
Gap Junctions:
Receptor(s):
Gene(s): HCN1;
Transmitter(s):
Simulation Environment: NEURON; neuroConstruct (web link to model);
Model Concept(s): Activity Patterns; Oscillations;
Implementer(s): D'Angelo, Egidio [dangelo at unipv.it]; De Schutter, Erik [erik at oist.jp];
Search NeuronDB for information about:  I Na,p; I Na,t; I T low threshold; I A; I K; I M; I h; I K,Ca; I Sodium; I Calcium; I Potassium;
Files displayed below are from the implementation
objectvar save_window_, rvp_
objectvar scene_vector_[5]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
{
save_window_ = new Graph(0)
save_window_.size(-100,5000,50,107)
scene_vector_[3] = save_window_
{save_window_.view(-100, 50, 5100, 57, 0, 621, 557.76, 319.36)}
graphList[1].append(save_window_)
save_window_.save_name("graphList[1].")
save_window_.label(0.5, 0, "time (ms)", 2, 1, 1, 0, 1)
save_window_.label(0, 0.5, "[ca] (nM)", 2, 1, 0, 1, 1)
save_window_.addexpr("Golgi[0].soma.cai( 0.5 )*1e6", 1, 1, 0.8, 0.9, 2)
save_window_.addexpr("Golgi[0].soma.ca2i( 0.5 )*1e6", 4, 1, 0.8, 0.9, 2)
}
objectvar scene_vector_[1]
{doNotify()}

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