Synchronization by D4 dopamine receptor-mediated phospholipid methylation (Kuznetsova, Deth 2008)

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Accession:112968
"We describe a new molecular mechanism of dopamine-induced membrane protein modulation that can tune neuronal oscillation frequency to attention related gamma rhythm. This mechanism is based on the unique ability of D4 dopamine receptors (D4R) to carry out phospholipid methylation (PLM) that may affect the kinetics of ion channels. We show that by deceasing the inertia of the delayed rectifier potassium channel, a transition to 40 Hz oscillations can be achieved. ..."
Reference:
1 . Kuznetsova AY, Deth RC (2008) A model for modulation of neuronal synchronization by D4 dopamine receptor-mediated phospholipid methylation. J Comput Neurosci 24:314-29 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network; Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism:
Cell Type(s): Neocortex V1 pyramidal corticothalamic L6 cell; Neocortex V1 pyramidal intratelencephalic L2-6 cell;
Channel(s): I Na,t; I T low threshold; I K; I K,Ca;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Dopamine;
Simulation Environment: XPP;
Model Concept(s): Activity Patterns; Oscillations; Synchronization; Simplified Models; Signaling pathways;
Implementer(s): Kuznetsova, Anna [anna.kuznetsova at utsa.edu];
Search NeuronDB for information about:  Neocortex V1 pyramidal corticothalamic L6 cell; Neocortex V1 pyramidal intratelencephalic L2-6 cell; I Na,t; I T low threshold; I K; I K,Ca; Dopamine;
# Kuznetsova and Deth, JCN, 2007
# 4-cell network, all-to-all connections: E cells (V1, V2) and I cells (V3, V4) 
init V1=-0.75  R1=0.26  CA1=0.1 H1=0.1
init V2=-0.71  R2=0.26  CA2=0.1 H2=0.1
init V3=-0.75  R3=0.26  CA3=0.1
init V4=-0.71  R4=0.26  CA4=0.1

init F1=0.0  S1=0.0  F2=0.0  S2=0.0 F3=0.0  S3=0.0  F4=0.0  S4=0.0
init F5=0.0  S5=0.0  F6=0.0  S6=0.0 F7=0.0  S7=0.0  F8=0.0  S8=0.0
init F9=0.0  S9=0.0  F10=0.0  S10=0.0 F11=0.0  S11=0.0  F12=0.0  S12=0.0

par Ie1=0.6, Ie2=0.6
#continuos input in both E cells

par GCA=0.1, GH=4.
par TR1=2.2, TR2=2.2
par GSYNee=6, GSYNei=6, TSYN=2, W=-0.1
#GSYNee=6 or 11

par GCAi=0.25
par TR3=1.5, TR4=1.5
par GSYNi=3, TSYNi=8
 
V1'=-MB(V1)*(V1-0.5)-26.*R1*(V1+0.95)-GCA*CA1*(V1-1.2)-GH*H1*(V1+0.95)-GSYNee*S1*(V1+0.0)-GSYNi*(V1+0.75)*(S2+S3)+Ie1  
R1'=(1./TR1)*(-R1+RB(V1))
CA1'=(1./14.)*(-CA1+CAB(V1))
H1'=(1./45.)*(-H1+3.*CA1)
F1'=(1./TSYN)*(-F1+heav(V2-W))
S1'=(1./TSYN)*(-S1+F1)
F2'=(1./TSYNi)*(-F2+heav(V3-W))
S2'=(1./TSYNi)*(-S2+F2)
F3'=(1./TSYNi)*(-F3+heav(V4-W))
S3'=(1./TSYNi)*(-S3+F3)

V2'=-MB(V2)*(V2-0.5)-26.*R2*(V2+0.95)-GCA*CA2*(V2-1.2)-GH*H2*(V2+0.95)-GSYNee*S4*(V2+0.0)-GSYNi*(V2+0.75)*(S5+S6)+Ie2
R2'=(1./TR2)*(-R2+RB(V2))
CA2'=(1./14.)*(-CA2+CAB(V2))
H2'=(1./45.)*(-H2+3.*CA2)
F4'=(1./TSYN)*(-F4+heav(V1-W))
S4'=(1./TSYN)*(-S4+F4)
F5'=(1./TSYNi)*(-F5+heav(V3-W))
S5'=(1./TSYNi)*(-S5+F5)
F6'=(1./TSYNi)*(-F6+heav(V4-W))
S6'=(1./TSYNi)*(-S6+F6)

V3'=-MB(V3)*(V3-0.5)-26.*R3*(V3+0.95)-GCAi*CA3*(V3-1.2)-GSYNi*S7*(V3+0.75)-GSYNei*(V3+0.0)*(S8+S9)
R3'=(1./TR3)*(-R3+RB(V3))
CA3'=(1./14.)*(-CA3+CAB(V3))
F7'=(1./TSYNi)*(-F7+heav(V4-W))
S7'=(1./TSYNi)*(-S7+F7)
F8'=(1./TSYN)*(-F8+heav(V1-W))
S8'=(1./TSYN)*(-S8+F8)
F9'=(1./TSYN)*(-F9+heav(V2-W))
S9'=(1./TSYN)*(-S9+F9)

V4'=-MB(V4)*(V4-0.5)-26.*R4*(V4+0.95)-GCAi*CA4*(V4-1.2)-GSYNi*S10*(V4+0.75)-GSYNei*(V4+0.0)*(S11+S12)
R4'=(1./TR4)*(-R4+RB(V4))
CA4'=(1./14.)*(-CA4+CAB(V4))
F10'=(1./TSYNi)*(-F10+heav(V4-W))
S10'=(1./TSYNi)*(-S10+F10)
F11'=(1./TSYN)*(-F11+heav(V1-W))
S11'=(1./TSYN)*(-S11+F11)
F12'=(1./TSYN)*(-F12+heav(V2-W))
S12'=(1./TSYN)*(-S12+F12)


CAB(V)=8.*(V+0.725)^2
MB(V)=17.8+47.6*V+33.8*V*V
RB(V)=1.24+3.7*V+3.2*V*V

um(Ve1,Ve2)=(Ve1+Ve2)/2

@ METHOD=stiff, TOLERANCE=.00001 BELL=0
@ dt=.01, total=600, xplot=t,yplot=CA1
@ xmin=0.0,xmax=600,ymin=-1.0,ymax=0.4
@ xlo=0.0,ylo=0.0,xhi=600,yhi=0.4,bound=30000,MAXSTOR=400000

aux n=um(V1,V2)

done

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