To examine the effect of glial K+ uptake, we used a model neuron equipped with Na+, K+, Ca2+ and Cl−
conductances, ion pumps and ion exchangers, surrounded by interstitial space and glia.
The glial membrane was either “passive”, incorporating only leak channels and an ion
exchange pump, or it had rectifying K+ channels. We computed ion fluxes, concentration changes and osmotic
We conclude that voltage gated K+ currents can boost the effectiveness of the glial “potassium buffer”
and that this buffer function is important even at moderate or low levels of excitation, but especially so in pathological states."
Somjen GG, Kager H, Wadman WJ (2008) Computer simulations of neuron-glia interactions mediated by ion flux. J Comp Neurosci 25(2):349-65 [PubMed]