MEG of Somatosensory Neocortex (Jones et al. 2007)

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Accession:113732
"... To make a direct and principled connection between the SI (somatosensory primary neocortex magnetoencephalography) waveform and underlying neural dynamics, we developed a biophysically realistic computational SI model that contained excitatory and inhibitory neurons in supragranular and infragranular layers. ... our model provides a biophysically realistic solution to the MEG signal and can predict the electrophysiological correlates of human perception."
Reference:
1 . Jones SR, Pritchett DL, Stufflebeam SM, Hämäläinen M, Moore CI (2007) Neural correlates of tactile detection: a combined magnetoencephalography and biophysically based computational modeling study. J Neurosci 27:10751-64 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell;
Channel(s): I T low threshold; I K; I M; I K,Ca; I Sodium; I Calcium; I R;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Magnetoencephalography; Touch;
Implementer(s): Sikora, Michael [Sikora at umn.edu];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; GabaA; GabaB; AMPA; NMDA; I T low threshold; I K; I M; I K,Ca; I Sodium; I Calcium; I R; Gaba; Glutamate;
NEURON {
: SUFFIX dipole
POINT_PROCESS Dipole
RANGE ri, ia, Q, ztan
POINTER pv

: POINTER Qsum : for density. sums into Dipole at section position 1
RANGE Qsum : for POINT_PROCESS. Gets additions from dipole
}

UNITS {
	(nA) = (nanoamp)
	(mV) =(millivolt)
	(Mohm) = (megaohm)
	(um) = (micrometer)
	(Am) = (amp meter)
	(fAm) = (femto amp meter)
}

ASSIGNED {
	ia (nA)
	ri (Mohm)
	pv (mV)
	v (mV)
	ztan (um)
	Q  (fAm)
	Qsum (fAm)
}

AFTER SOLVE {     	: solve for v's first then use them
	ia=(pv-v)/ri
	Q=ia*ztan
	Qsum = Qsum + Q
}
	
AFTER INITIAL {
	ia=(pv-v)/ri
	Q=ia*ztan
	Qsum = Qsum + Q
}

: following needed for POINT_PROCESS only but will work if also in SUFFIX
 BEFORE INITIAL {
	Qsum = 0
 }
 BEFORE BREAKPOINT {
	Qsum = 0
 }


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