MEG of Somatosensory Neocortex (Jones et al. 2007)

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Accession:113732
"... To make a direct and principled connection between the SI (somatosensory primary neocortex magnetoencephalography) waveform and underlying neural dynamics, we developed a biophysically realistic computational SI model that contained excitatory and inhibitory neurons in supragranular and infragranular layers. ... our model provides a biophysically realistic solution to the MEG signal and can predict the electrophysiological correlates of human perception."
Reference:
1 . Jones SR, Pritchett DL, Stufflebeam SM, Hämäläinen M, Moore CI (2007) Neural correlates of tactile detection: a combined magnetoencephalography and biophysically based computational modeling study. J Neurosci 27:10751-64 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Neocortex L5/6 pyramidal GLU cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell;
Channel(s): I T low threshold; I K; I M; I K,Ca; I Sodium; I Calcium; I R;
Gap Junctions:
Receptor(s): GabaA; GabaB; AMPA; NMDA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Magnetoencephalography; Touch;
Implementer(s): Sikora, Michael [Sikora at umn.edu];
Search NeuronDB for information about:  Neocortex L5/6 pyramidal GLU cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; GabaA; GabaB; AMPA; NMDA; I T low threshold; I K; I M; I K,Ca; I Sodium; I Calcium; I R; Gaba; Glutamate;
: $Id: precall.mod,v 1.3 1995/12/16 19:00:01 billl Exp $

COMMENT
presynaptic pointer array
ENDCOMMENT

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

NEURON {
  POINT_PROCESS PRESYN
  RANGE spk_internal, spk, num
  GLOBAL thresh
}

PARAMETER {
  thresh = -20 			: voltage level nec for release
  num = -1	                : number for reporting spk occurrence
}

ASSIGNED { 
  spk                           : available for user monitoring of spiking
  spk_internal                  : internal use only (if taken externally ...)
  v
}

INCLUDE "presyn.inc"

INITIAL {
  spk = 0
  spk_internal = 0
}

BREAKPOINT {
  SOLVE pp
}

PROCEDURE pp() {
  if (v > thresh) {    
    if (spk_internal == 0) {
      newspike()                : only allow this to happen once
      spk_internal = 1
      spk = 1
      VERBATIM
      { extern double hoc_call_func();
      char func[8] = "precall";
      Symbol* s = hoc_lookup(func);
      if (s && num>=0) {
        hoc_pushx(num);
        hoc_call_func(s, 1);
      }
      }
      ENDVERBATIM
    }
  } else { 
    spk_internal = 0            : drop back down at the end of the spike
    spk = 0
  }
}

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