Systems-level modeling of neuronal circuits for leech swimming (Zheng et al. 2007)

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Accession:114230
"This paper describes a mathematical model of the neuronal central pattern generator (CPG) that controls the rhythmic body motion of the swimming leech. The systems approach is employed to capture the neuronal dynamics essential for generating coordinated oscillations of cell membrane potentials by a simple CPG architecture with a minimal number of parameters. ... parameter estimation leads to predictions regarding the synaptic coupling strength and intrinsic period gradient along the nerve cord, the latter of which agrees qualitatively with experimental observations."
Reference:
1 . Zheng M, Friesen WO, Iwasaki T (2007) Systems-level modeling of neuronal circuits for leech swimming. J Comput Neurosci 22:21-38 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type:
Brain Region(s)/Organism: Leech;
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Temporal Pattern Generation; Oscillations; Simplified Models;
Implementer(s):
% variable used: nn, r, mu, t0, pl, tdp , gain, backgain

% nn---number of RCIs
% rr ---motor neuron input
% mu --Intrasegmental connection strength
% t0---Intrinsic time constant
% pl---projection length
% tdp--time deplay per segment
% delta, eta ---strength ratio

  

tmax=20;
%   time=linspace(0,tmax,nsmpl)';

nn=17;
rr=0.3*ones(nn,1); 
mu=6;
t0=ones(nn,1)*0.200; 	% intrinsic time constant is 200 ms uniformaly for all segments
ee=30;
pl=5;
td=0.015;		% time delay per segment is 15 ms
delta=0.01;
eta=2;


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