Homeostatic synaptic plasticity (Rabinowitch and Segev 2006a,b)

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(2006a): "We investigated analytically and numerically the interplay between two opposing forms of synaptic plasticity: positive-feedback, long-term potentiation/depression (LTP/LTD), and negative-feedback, homeostatic synaptic plasticity (HSP). A detailed model of a CA1 pyramidal neuron, with numerous HSP-modifiable dendritic synapses, demonstrates that HSP may have an important role in selecting which spatial patterns of LTP/LTD are to last. ... Despite the negative-feedback nature of HSP, under both local and global HSP, numerous synaptic potentiations/depressions can persist. These experimentally testable results imply that HSP could be significantly involved in shaping the spatial distribution of synaptic weights in the dendrites and not just normalizing it, as is currently believed." (2006b): "Homeostatic synaptic plasticity (HSP) is an important mechanism attributed with the slow regulation of the neuron's activity. Whenever activity is chronically enhanced, HSP weakens the weights of the synapses in the dendrites and vice versa. Because dendritic morphology and its electrical properties partition the dendritic tree into functional compartments, we set out to explore the interplay between HSP and dendritic compartmentalization. ... The spatial distribution of synaptic weights throughout the dendrites will markedly differ under the local versus global HSP mechanisms. We suggest an experimental paradigm to unravel which type of HSP mechanism operates in the dendritic tree. The answer to this question will have important implications to our understanding of the functional organization of the neuron."
Reference:
1 . Rabinowitch I, Segev I (2006b) The interplay between homeostatic synaptic plasticity and functional dendritic compartments. J Neurophysiol 96:276-83 [PubMed]
2 . Rabinowitch I, Segev I (2006a) The endurance and selectivity of spatial patterns of long-term potentiation-depression in dendrites under homeostatic synaptic plasticity. J Neurosci 26:13474-84 [PubMed]
3 . Rabinowitch I, Segev I (2008) Two opposing plasticity mechanisms pulling a single synapse. Trends Neurosci [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON; MATLAB;
Model Concept(s): Synaptic Plasticity;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; I Na,t; I A; I K;

Rabinowitch I, Segev I (2006b) The interplay between homeostatic synaptic plasticity and functional dendritic compartments. J Neurophysiol 96:276-83[PubMed]

References and models cited by this paper

References and models that cite this paper

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   [22 reconstructed morphologies on NeuroMorpho.Org]
   Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites (Golding et al 2001) [Model]

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Ferrante M, Migliore M, Ascoli GA (2013) Functional Impact of Dendritic Branch-Point Morphology J. Neurosci. 33:2156-2165 [Journal]

   Functional impact of dendritic branch point morphology (Ferrante et al., 2013) [Model]

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Rabinowitch I, Segev I (2006a) The endurance and selectivity of spatial patterns of long-term potentiation-depression in dendrites under homeostatic synaptic plasticity. J Neurosci 26:13474-84 [Journal] [PubMed]

   Homeostatic synaptic plasticity (Rabinowitch and Segev 2006a,b) [Model]

Rabinowitch I, Segev I (2008) Two opposing plasticity mechanisms pulling a single synapse. Trends Neurosci [Journal] [PubMed]

   Homeostatic synaptic plasticity (Rabinowitch and Segev 2006a,b) [Model]

(55 refs)

Rabinowitch I, Segev I (2006a) The endurance and selectivity of spatial patterns of long-term potentiation-depression in dendrites under homeostatic synaptic plasticity. J Neurosci 26:13474-84[PubMed]

References and models cited by this paper

References and models that cite this paper

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   [22 reconstructed morphologies on NeuroMorpho.Org]
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   Homeostatic synaptic plasticity (Rabinowitch and Segev 2006a,b) [Model]

(60 refs)

Rabinowitch I, Segev I (2008) Two opposing plasticity mechanisms pulling a single synapse. Trends Neurosci[PubMed]

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