Na+ channel dependence of AP initiation in cortical pyramidal neuron (Kole et al. 2008)

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In this simulation action potential initiation, action potential properties and the role of axon initial segment Na+ channels are investigated in a realistic model of a layer 5 pyramidal neuron axon initial segment. The main Na+ channel properties were constrained by experimental data and the axon initial segment was reconstructed. Model parameters were constrained by direct recordings at the axon initial segment.
1 . Kole MH, Ilschner SU, Kampa BM, Williams SR, Ruben PC, Stuart GJ (2008) Action potential generation requires a high sodium channel density in the axon initial segment. Nat Neurosci 11:178-86 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Neocortex layer 5-6 pyramidal cell;
Channel(s): I Na,t; I K; I M; I h;
Gap Junctions:
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Active Dendrites; Axonal Action Potentials; Action Potentials;
Implementer(s): Kole, Maarten [m.kole at];
Search NeuronDB for information about:  Neocortex layer 5-6 pyramidal cell; I Na,t; I K; I M; I h;

Kole MH, Ilschner SU, Kampa BM, Williams SR, Ruben PC, Stuart GJ (2008) Action potential generation requires a high sodium channel density in the axon initial segment. Nat Neurosci 11:178-86[PubMed]

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