of propofol, an intravenous anesthetic agent with a distinct chemical structure,
on ion currents of differentiated clonal cardiac (H9c2) cells were investigated
in this study.
Propofol ... suppressed the amplitude of delayed
rectifier K(+) current (I(K(DR))) in a concentration-dependent manner with
an IC(50) value of 36 muM.
Propofol (30 muM) had no effect on erg-mediated K(+)
current in these cells; however, it suppressed L-type Ca(2+) current (I(Ca,L))
of cardiac and skeletal types to a similar extent.
simulations of I(K(DR)) based on a Markovian model reproduce the
experimental results and show that propofol-induced blockade of I(K(DR))
is associated with an decrease in forward rate of the activation process and
an increase in transitional rate into the inactivated state.
Liu YC, Wang YJ, Wu SN (2008) The mechanisms of propofol-induced block on ion currents in differentiated H9c2 cardiac cells. Eur J Pharmacol 590:93-8 [PubMed]