Olfactory bulb mitral and granule cell column formation (Migliore et al. 2007)

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Accession:114665
In the olfactory bulb, the processing units for odor discrimination are believed to involve dendrodendritic synaptic interactions between mitral and granule cells. There is increasing anatomical evidence that these cells are organized in columns, and that the columns processing a given odor are arranged in widely distributed arrays. Experimental evidence is lacking on the underlying learning mechanisms for how these columns and arrays are formed. We have used a simplified realistic circuit model to test the hypothesis that distributed connectivity can self-organize through an activity-dependent dendrodendritic synaptic mechanism. The results point to action potentials propagating in the mitral cell lateral dendrites as playing a critical role in this mechanism, and suggest a novel and robust learning mechanism for the development of distributed processing units in a cortical structure.
Reference:
1 . Migliore M, Inzirillo C, Shepherd GM (2007) Learning mechanism for column formation in the olfactory bulb. Front Integr Neurosci 1:12 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Olfactory bulb;
Cell Type(s): Olfactory bulb main mitral cell; Olfactory bulb main interneuron granule MC cell;
Channel(s): I Na,t; I A; I K;
Gap Junctions:
Receptor(s): AMPA; NMDA; Gaba;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Synaptic Plasticity; Long-term Synaptic Plasticity; Action Potentials; Learning; Olfaction;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Olfactory bulb main mitral cell; Olfactory bulb main interneuron granule MC cell; AMPA; NMDA; Gaba; I Na,t; I A; I K; Gaba; Glutamate;
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plast
readme.html
kamt.mod *
kdrmt.mod *
naxn.mod *
nmdanetOB.mod *
2mc-w05-w00-e2i3-int220.hoc
2mt-s1-w05-w00-e2i3-int220.txt
2mt-s2-w05-w00-e2i3-int220.txt
2mt-s4-w05-w00-e2i3-int220.txt
gc-plast.hoc
mitral-plast-2.hoc
mosinit.hoc
plasticity-disp.hoc
screenshot.jpg
trace-gc0dend0-w05-w00-e2i3-int220.txt
trace-gc33dend0-w05-w00-e2i3-int220.txt
trace-mt0dend066-w05-w00-e2i3-int220.txt
trace-mt0soma05-w05-w00-e2i3-int220.txt
trace-time-w05-w00-e2i3-int220.txt
                            
begintemplate Mitral

// ls - long secondary dendrites 

public soma, priden, secden, tuftden, hillock, initialseg
public dendritic, somatic, second, somden, synodor, isynpg
public dampa, igp


create soma, priden, secden[2], tuftden, hillock, initialseg

forall {Ra = 150}

objref dendritic, somatic, somden, synodor
objref igp[2][50]

proc init() {

dendritic = new SectionList()
forsec "priden" dendritic.append()
forsec "secden" dendritic.append()
forsec "tuftden" dendritic.append()

somatic = new SectionList()
soma somatic.append
hillock somatic.append

somden = new SectionList()
forsec somatic somden.append()
forsec dendritic somden.append()

topol()
segments()
geometry()
memb()

}


proc topol() {local i
	connect secden[0](0), soma(.5)
	connect secden[1](0), soma(.5)
	connect priden(0), soma(1)
	connect tuftden(0), priden(1)

	connect hillock(0), soma(0)
	connect initialseg(0), hillock(1)
}

proc segments() {local i
	soma.nseg= 1
	priden.nseg = 5
	forsec "tuftden" nseg = 10
	forsec "secden" nseg = 50
	initialseg.nseg = 3
	hillock.nseg = 3
}

proc geometry() {local i
	soma { L = 25  diam = 20 }
	priden { L = 300  diam = 3 }
	forsec "tuftden" {rallbranch=20 L=300  diam(0:1)=.4:.4 }
	forsec "secden" { L=500  diam=2 }
	initialseg{ L=30  diam=1.5}
	hillock { L=5  diam(0:1) = soma.diam(0) : initialseg.diam(0) }
	define_shape()
}
	


proc memb() {
	forall {insert pas}
	forsec somden {
		insert nax  insert kamt insert kdrmt
		ek = -90
		ena = 50
		gbar_nax = 0.04 sh_nax=10
	 	gbar_kdrmt = 0.0001
		gbar_kamt = 0.004
		}

	forall {Ra = 150}

	totarea=0
	forall {
		cm = 1.8
		g_pas = 1/12000
		e_pas = -65
	}

	initialseg {
		insert nax  insert kamt insert kdrmt
		ek = -90
		ena = 50
	        g_pas = 1/1000
	        gbar_nax = 0.8
		sh_nax = 0
	        gbar_kamt = 0.08
	        gbar_kdrmt = 0.0001
	}       

  
	tuftden {
	synodor = new Exp2Syn(.2)
	synodor.e=0
	synodor.tau1 = 20
	synodor.tau2 = 200

}

for i=0, 1 secden[i] {
	for j=0, 49 {
		igp[i][j] = new Exp2Syn(j*.02)
		igp[i][j].e=-80
		igp[i][j].tau1 = 1
		igp[i][j].tau2 = 200
	}
}

}

endtemplate Mitral

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