High frequency oscillations induced in three gap-junction coupled neurons (Tseng et al. 2008)

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Accession:114735
Here we showed experimentally that high frequency oscillations (up to 600 Hz) were easily induced in a purely gap-junction coupled network by simple two stimuli with very short interval. The root cause is that the second elicited spike suffered from slow propagation speed and failure to transmit through a low-conductance junction. Similiar results were also obtained in these simulation.
Reference:
1 . Tseng SH, Tsai LY, Yeh SR (2008) Induction of high-frequency oscillations in a junction-coupled network. J Neurosci 28:7165-73 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Axon;
Brain Region(s)/Organism:
Cell Type(s): Hodgkin-Huxley neuron;
Channel(s):
Gap Junctions: Gap junctions;
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Axonal Action Potentials; Action Potentials; Delay; Conduction failure;
Implementer(s): Tseng, Shin-Hua ;
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