Axonal Projection and Interneuron Types (Helmstaedter et al. 2008)


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Accession:116053
"Interneurons in layer 2/3 (L2/3) of the somatosensory cortex show 4 types of axonal projection patterns with reference to the laminae and borders of columns in rat barrel cortex (Helmstaedter et al. 2008a). Here, we analyzed the dendritic geometry and electrical excitability of these interneurons. ... We conclude that 1) dendritic polarity is correlated to intrinsic electrical excitability, and 2) the axonal projection pattern represents an independent classifier of interneurons. "
References:
1 . Helmstaedter M, Sakmann B, Feldmeyer D (2009) The Relation between Dendritic Geometry, Electrical Excitability, and Axonal Projections of L2-3 Interneurons in Rat Barrel Cortex. Cereb Cortex 19:938-950 [PubMed]
2 . Helmstaedter M, Sakmann B, Feldmeyer D (2008) Neuronal Correlates of Local, Lateral, and Translaminar Inhibition with Reference to Cortical Columns. Cereb Cortex [PubMed]
3 . Helmstaedter M, Sakmann B, Feldmeyer D (2008) L2/3 Interneuron Groups Defined by Multiparameter Analysis of Axonal Projection, Dendritic Geometry, and Electrical Excitability. Cereb Cortex [PubMed]
4 . Helmstaedter M, Staiger JF, Sakmann B, Feldmeyer D (2008) Efficient recruitment of layer 2-3 interneurons by layer 4 input in single columns of rat somatosensory cortex. J Neurosci 28:8273-84 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s):
Channel(s): I Na,t; I L high threshold; I K; I M; I K,Ca;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON (web link to model);
Model Concept(s): Influence of Dendritic Geometry;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I L high threshold; I K; I M; I K,Ca;
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