Spine neck plasticity controls postsynaptic calcium signals (Grunditz et al. 2008)

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Accession:116769
This model was set up to dissect the relative contribution of different channels to the spine calcium transients measured at single spines.
Reference:
1 . Grunditz A, Holbro N, Tian L, Zuo Y, Oertner TG (2008) Spine Neck Plasticity Controls Postsynaptic Calcium Signals through Electrical Compartmentalization J Neurosci 28(50):13457-13466 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s): I Calcium; I R;
Gap Junctions:
Receptor(s): AMPA; NMDA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Calcium dynamics;
Implementer(s): Mueller, Asa [asa.mueller at fmi.ch];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; AMPA; NMDA; I Calcium; I R; Glutamate;
/********************************************************************
Create a spine with a spine neck 
connected to the parant dendrite dendA5_00
*************************************************/

{create spine_neck}
{dendA5_00 connect spine_neck(0),0.8}
{access spine_neck}
necklength = 1  /*spine neck length in um*/
neckdiam = 0.0394 /*spine neck diameter*/
spine_neck {nseg = 2
            pt3dclear()
            for j = 0, nseg-1 {
                ty = (j*necklength)/(nseg-1)
                pt3dadd(97.58,ty,20.87,neckdiam)
                }
            }

{create spine_head}
{spine_neck connect spine_head(0), 1}
{access spine_head}
spineradius = 0.297
spine_head {nseg = 7
            pt3dclear()
            for i = 0, nseg-1 {
                ty = -(i*2*spineradius)/(nseg-1)
                td = 2*sqrt(spineradius^2-(ty+spineradius)^2)
                if (td<neckdiam){
                    td = neckdiam
                    } 
                    pt3dadd(97.58,ty+1,20.87,td)
                }
            }

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