Thalamic interneuron multicompartment model (Zhu et al. 1999)

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Accession:116862
This is an attempt to recreate a set of simulations originally performed in 1994 under NEURON version 3 and last tested in 1999. When I ran it now it did not behave exactly the same as previously which I suspect is due to some minor mod file changes on my side rather than due to any differences among versions. After playing around with the parameters a little bit I was able to get something that looks generally like a physiological trace in J Neurophysiol, 81:702--711, 1999, fig. 8b top trace. This sad preface is simply offered in order to encourage anyone who is interested in this model to make and post fixes. I'm happy to help out. Simulation by JJ Zhu To run nrnivmodl nrngui.hoc
References:
1 . Zhu JJ, Uhlrich DJ, Lytton WW (1999) Burst firing in identified rat geniculate interneurons. Neuroscience 91:1445-60 [PubMed]
2 . Zhu JJ, Lytton WW, Xue JT, Uhlrich DJ (1999) An intrinsic oscillation in interneurons of the rat lateral geniculate nucleus. J Neurophysiol 81:702-11 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Thalamus;
Cell Type(s):
Channel(s): I Na,t; I L high threshold; I T low threshold; I K,leak; I h; I K,Ca; I CAN;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Oscillations;
Implementer(s): Zhu, J. Julius [jjzhu at virginia.edu];
Search NeuronDB for information about:  I Na,t; I L high threshold; I T low threshold; I K,leak; I h; I K,Ca; I CAN;
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b09jan13
readme.html
AMPA.mod
cadecay.mod
clampex.mod *
cp.mod *
cp2.mod *
GABAA.mod
GABAB.mod
HH2.mod *
Iahp.mod *
Ican.mod *
Ih.mod *
IL.mod
IL3.mod *
IT.mod *
IT2.mod *
kdr2.mod *
kleak.mod *
kmbg.mod
naf2.mod *
nap.mod *
NMDA.mod
nthh.mod *
ntIh.mod *
ntleak.mod
ntt.mod *
pregencv.mod
vecst.mod
batch_.hoc
batch_.hoc'A=0
bg_cvode.inc
misc.h
mosinit.hoc *
netcon.inc
screenshot.jpg
                            
NEURON{ POINT_PROCESS NMDA
  RANGE B 
  GLOBAL mg
}

PARAMETER {
  mg        = 1.    (mM)       : external magnesium concentration
  Cdur	= 1.	(ms)	   : transmitter duration (rising phase)
  Alpha	= 4.	(/ms mM)   : forward (binding) rate
  Beta	= 0.0067 (/ms)	   : backward (unbinding) rate 1/150
  Erev	= 0.	(mV)	   : reversal potential
}

ASSIGNED { B }

INCLUDE "netcon.inc"
: EXTRA BREAKPOINT MUST BE BELOW THE INCLUDE
BREAKPOINT {
  rates(v)
  g = g * B : hence g = gmax * R * B
  i = i * B : hence i = g*(v - Erev)
}

PROCEDURE rates(v(mV)) {
  TABLE B
  DEPEND mg
  FROM -100 TO 80 WITH 180
  B = 1 / (1 + exp(0.062 (/mV) * -v) * (mg / 3.57 (mM)))
}
:** GABAA - a GABAA for intra-RE connects

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