Working memory circuit with branched dendrites (Morita 2008)

 Download zip file 
Help downloading and running models
Accession:117204
This is a rate-coding model of the neocortical spatial working memory circuit incorporating multiple dendritic branches of the individual pyramidal cell in order to examine how nonlinear dendritic integration, combined with the nonuniform distribution of the external input, affects the behavior of the whole circuit.
Reference:
1 . Morita K (2008) Possible role of dendritic compartmentalization in the spatial working memory circuit. J Neurosci 28:7699-724 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: MATLAB;
Model Concept(s): Working memory;
Implementer(s): Morita, Kenji [morita at p.u-tokyo.ac.jp];

Morita K (2008) Possible role of dendritic compartmentalization in the spatial working memory circuit. J Neurosci 28:7699-724[PubMed]

References and models cited by this paper

References and models that cite this paper

Amari S (1977) Dynamics of pattern formation in lateral-inhibition type neural fields. Biol Cybern 27:77-87 [PubMed]

Amari S, Arbib MA (1977) Competition and cooperation in neural nets Systems neuroscience, Metzler J, ed. pp.119

Archie KA, Mel BW (2000) A model for intradendritic computation of binocular disparity. Nat Neurosci 3:54-63 [Journal] [PubMed]

   Visual Cortex Neurons: Dendritic computations (Archie, Mel 2000) [Model]

Basso MA, Wurtz RH (1997) Modulation of neuronal activity by target uncertainty. Nature 389:66-9 [PubMed]

Beierlein M, Gibson JR, Connors BW (2003) Two dynamically distinct inhibitory networks in layer 4 of the neocortex. J Neurophysiol 90:2987-3000 [Journal] [PubMed]

Bisley JW, Goldberg ME (2003) Neuronal activity in the lateral intraparietal area and spatial attention. Science 299:81-6 [PubMed]

Camperi M, Wang XJ (1998) A model of visuospatial working memory in prefrontal cortex: recurrent network and cellular bistability. J Comput Neurosci 5:383-405 [Journal] [PubMed]

Carandini M, Heeger DJ (1994) Summation and division by neurons in primate visual cortex. Science 264:1333-6 [PubMed]

Carter E, Wang XJ (2007) Cannabinoid-mediated disinhibition and working memory: dynamical interplay of multiple feedback mechanisms in a continuous attractor model of prefrontal cortex. Cereb Cortex 17 Suppl 1:i16-26

Cash S, Yuste R (1999) Linear summation of excitatory inputs by CA1 pyramidal neurons. Neuron 22:383-94 [PubMed]

Chance FS, Abbott LF, Reyes AD (2002) Gain modulation from background synaptic input. Neuron 35:773-82 [PubMed]

Compte A, Brunel N, Goldman-Rakic PS, Wang XJ (2000) Synaptic mechanisms and network dynamics underlying spatial working memory in a cortical network model. Cereb Cortex 10:910-23 [PubMed]

Constantinidis C, Steinmetz MA (2001) Neuronal responses in area 7a to multiple-stimulus displays: I. neurons encode the location of the salient stimulus. Cereb Cortex 11:581-91 [PubMed]

Constantinidis C, Wang XJ (2004) A neural circuit basis for spatial working memory. Neuroscientist 10:553-65 [PubMed]

Constantinidis C, Williams GV, Goldman-Rakic PS (2002) A role for inhibition in shaping the temporal flow of information in prefrontal cortex. Nat Neurosci 5:175-80 [PubMed]

Elston GN (2003) Cortex, cognition and the cell: new insights into the pyramidal neuron and prefrontal function. Cereb Cortex 13:1124-38 [PubMed]

Fall CP, Rinzel J (2006) An intracellular Ca2+ subsystem as a biologically plausible source of intrinsic conditional bistability in a network model of working memory J Comput Neurosci 20:97-107 [Journal] [PubMed]

Fukai T, Tanaka S (1997) A simple neural network exhibiting selective activation of neuronal ensembles: from winner-take-all to winners-share-all. Neural Comput 9:77-97 [PubMed]

Funahashi S, Bruce CJ, Goldman-Rakic PS (1989) Mnemonic coding of visual space in the monkey's dorsolateral prefrontal cortex. J Neurophysiol 61:331-49 [Journal] [PubMed]

Galarreta M, Hestrin S (1998) Frequency-dependent synaptic depression and the balance of excitation and inhibition in the neocortex. Nat Neurosci 1:587-94 [PubMed]

Gao WJ, Wang Y, Goldman-Rakic PS (2003) Dopamine modulation of perisomatic and peridendritic inhibition in prefrontal cortex. J Neurosci 23:1622-30 [PubMed]

Gasparini S, Magee JC (2006) State-dependent dendritic computation in hippocampal CA1 pyramidal neurons. J Neurosci 26:2088-100 [PubMed]

Gibson JR, Beierlein M, Connors BW (1999) Two networks of electrically coupled inhibitory neurons in neocortex. Nature 402:75-9 [PubMed]

Gold JI, Shadlen MN (2007) The neural basis of decision making. Annu Rev Neurosci 30:535-74 [PubMed]

Golding NL, Staff NP, Spruston N (2002) Dendritic spikes as a mechanism for cooperative long-term potentiation. Nature 418:326-31 [PubMed]

Goldman MS, Levine JH, Major G, Tank DW, Seung HS (2003) Robust persistent neural activity in a model integrator with multiple hysteretic dendrites per neuron. Cereb Cortex 13:1185-95 [PubMed]

Goldman MS, Maldonado P, Abbott LF (2002) Redundancy reduction and sustained firing with stochastic depressing synapses. J Neurosci 22:584-91 [PubMed]

Goldman-Rakic PS (1995) Cellular basis of working memory. Neuron 14:477-85 [PubMed]

Gonzalez-Burgos G, Krimer LS, Povysheva NV, Barrionuevo G, Lewis DA (2005) Functional properties of fast spiking interneurons and their synaptic connections with pyramidal cells in primate dorsolateral prefrontal cortex. J Neurophysiol 93:942-53 [PubMed]

   [1 reconstructed morphology on NeuroMorpho.Org]

Gonzalez-Burgos G, Krimer LS, Urban NN, Barrionuevo G, Lewis DA (2004) Synaptic efficacy during repetitive activation of excitatory inputs in primate dorsolateral prefrontal cortex. Cereb Cortex 14:530-42 [PubMed]

   [1 reconstructed morphology on NeuroMorpho.Org]

Govindarajan A, Kelleher RJ, Tonegawa S (2006) A clustered plasticity model of long-term memory engrams. Nat Rev Neurosci 7:575-83 [PubMed]

Gupta A, Wang Y, Markram H (2000) Organizing principles for a diversity of GABAergic interneurons and synapses in the neocortex. Science 287:273-8 [PubMed]

   [4 reconstructed morphologies on NeuroMorpho.Org]

Gutkin BS, Laing CR, Colby CL, Chow CC, Ermentrout GB (2001) Turning on and off with excitation: the role of spike-timing asynchrony and synchrony in sustained neural activity. J Comput Neurosci 11:121-34 [Journal] [PubMed]

Hahnloser RH, Sarpeshkar R, Mahowald MA, Douglas RJ, Seung HS (2000) Digital selection and analogue amplification coexist in a cortex-inspired silicon circuit. Nature 405:947-51 [PubMed]

Harvey CD, Svoboda K (2007) Locally dynamic synaptic learning rules in pyramidal neuron dendrites. Nature 450:1195-200 [PubMed]

Hausser M, Mel B (2003) Dendrites: bug or feature? Curr Opin Neurobiol 13:372-83 [PubMed]

Herz AV, Gollisch T, Machens CK, Jaeger D (2006) Modeling single-neuron dynamics and computations: a balance of detail and abstraction. Science 314:80-5 [PubMed]

Ho N, Destexhe A (2000) Synaptic background activity enhances the responsiveness of neocortical pyramidal neurons. J Neurophysiol 84:1488-96 [Journal] [PubMed]

Holt GR, Koch C (1997) Shunting inhibition does not have a divisive effect on firing rates. Neural Comput 9:1001-13 [PubMed]

Jadi M, Mel BW (2007) Synchrony and location dependent effects of inhibition in a pyramidal neuron model 007 Computational and Systems Neuroscience Meeting

Kapfer C, Glickfeld LL, Atallah BV, Scanziani M (2007) Supralinear increase of recurrent inhibition during sparse activity in the somatosensory cortex. Nat Neurosci 10:743-53 [PubMed]

Kastner S, DeSimone K, Konen CS, Szczepanski SM, Weiner KS, Schneider KA (2007) Topographic maps in human frontal cortex revealed in memory-guided saccade and spatial working-memory tasks. J Neurophysiol 97:3494-507 [PubMed]

Kawaguchi Y, Kubota Y (1997) GABAergic cell subtypes and their synaptic connections in rat frontal cortex. Cereb Cortex 7:476-86 [PubMed]

Koch C, Poggio T, Torre V (1983) Nonlinear interactions in a dendritic tree: localization, timing, and role in information processing. Proc Natl Acad Sci U S A 80:2799-802 [PubMed]

Kubota Y, Hatada S, Kondo S, Karube F, Kawaguchi Y (2007) Neocortical inhibitory terminals innervate dendritic spines targeted by thalamocortical afferents. J Neurosci 27:1139-50 [PubMed]

Liu G (2004) Local structural balance and functional interaction of excitatory and inhibitory synapses in hippocampal dendrites. Nat Neurosci 7:373-9 [PubMed]

Logothetis NK, Wandell BA (2004) Interpreting the BOLD signal. Annu Rev Physiol 66:735-69 [PubMed]

London M, Hausser M (2005) Dendritic computation. Annu Rev Neurosci 28:503-32 [PubMed]

Losonczy A, Magee JC (2006) Integrative properties of radial oblique dendrites in hippocampal CA1 pyramidal neurons. Neuron 50:291-307 [PubMed]

Losonczy A, Makara JK, Magee JC (2008) Compartmentalized dendritic plasticity and input feature storage in neurons. Nature 452:436-41 [PubMed]

Mainen ZF, Joerges J, Huguenard JR, Sejnowski TJ (1995) A model of spike initiation in neocortical pyramidal neurons. Neuron 15:1427-39 [PubMed]

   Spike Initiation in Neocortical Pyramidal Neurons (Mainen et al 1995) [Model]

Mainen ZF, Sejnowski TJ (1996) Influence of dendritic structure on firing pattern in model neocortical neurons. Nature 382:363-6 [Journal] [PubMed]

   [2 reconstructed morphologies on NeuroMorpho.Org]
   Pyramidal Neuron Deep, Superficial; Aspiny, Stellate (Mainen and Sejnowski 1996) [Model]

Markram H, Toledo-Rodriguez M, Wang Y, Gupta A, Silberberg G, Wu C (2004) Interneurons of the neocortical inhibitory system. Nat Rev Neurosci 5:793-807 [Journal] [PubMed]

Matsuzaki M (2007) Factors critical for the plasticity of dendritic spines and memory storage. Neurosci Res 57:1-9 [PubMed]

Mehta MR (2004) Cooperative LTP can map memory sequences on dendritic branches. Trends Neurosci 27:69-72 [PubMed]

Mel BW (1993) Synaptic integration in an excitable dendritic tree. J Neurophysiol 70:1086-101 [Journal] [PubMed]

Mel BW (2007) Why have dendrites? A computational perspective. Dendrites, Ed 2, Stuart GJ:Spruston N:Hausser M, ed. pp.351

Mel BW, Ruderman DL, Archie KA (1998) Translation-invariant orientation tuning in visual "complex" cells could derive from intradendritic computations. J Neurosci 18:4325-34 [PubMed]

Milojkovic BA, Radojicic MS, Antic SD (2005) A strict correlation between dendritic and somatic plateau depolarizations in the rat prefrontal cortex pyramidal neurons. J Neurosci 25:3940-51 [PubMed]

Milojkovic BA, Zhou WL, Antic SD (2007) Voltage and calcium transients in basal dendrites of the rat prefrontal cortex. J Physiol 585:447-68 [PubMed]

Morita K, Aihara K (2005) A network model with pyramidal cells and GABAergic non-FS cells in the cerebral cortex Neurocomputing 65:697-707

Morita K, Amari S-I (2007) A field equation model of the neuronal network dynamics incorporating two stages of nonlinear input integrations in individual neurons Soc Neurosci Abstr 33:753-6

Morita K, Okada M, Aihara K (2007) Selectivity and stability via dendritic nonlinearity. Neural Comput 19:1798-853 [PubMed]

Nevian T, Larkum ME, Polsky A, Schiller J (2007) Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study. Nat Neurosci 10:206-14 [Journal] [PubMed]

   Dendritic Na+ spike initiation and backpropagation of APs in active dendrites (Nevian et al. 2007) [Model]

Pinsky PF, Rinzel J (1994) Intrinsic and network rhythmogenesis in a reduced Traub model for CA3 neurons. J Comput Neurosci 1:39-60 [Journal] [PubMed]

   CA3 pyramidal cell: rhythmogenesis in a reduced Traub model (Pinsky, Rinzel 1994) [Model]

Platt ML, Glimcher PW (1999) Neural correlates of decision variables in parietal cortex. Nature 400:233-8 [PubMed]

Poirazi P, Brannon T, Mel BW (2003a) Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron 37:977-987 [Journal] [PubMed]

   CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003) [Model]

Poirazi P, Brannon T, Mel BW (2003b) Pyramidal Neuron as Two-Layer Neural Network. Neuron 37:989-999 [Journal] [PubMed]

   CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003) [Model]

Poirazi P, Mel BW (2001) Impact of active dendrites and structural plasticity on the memory capacity of neural tissue. Neuron 29:779-96 [PubMed]

Polsky A, Mel BW, Schiller J (2004) Computational subunits in thin dendrites of pyramidal cells. Nat Neurosci 7:621-7 [Journal] [PubMed]

   CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003) [Model]

Prescott SA, De Koninck Y (2003) Gain control of firing rate by shunting inhibition: roles of synaptic noise and dendritic saturation. Proc Natl Acad Sci U S A 100:2076-81 [PubMed]

Rall W (1964) Theoretical significance of dendritic trees for neuronal input output relations Neural Theory and Modeling, Reiss RF, ed. pp.73 [Journal]

   Effects of synaptic location and timing on synaptic integration (Rall 1964) [Model]

Rao SG, Williams GV, Goldman-Rakic PS (1999) Isodirectional tuning of adjacent interneurons and pyramidal cells during working memory: evidence for microcolumnar organization in PFC. J Neurophysiol 81:1903-16 [Journal] [PubMed]

Rao SG, Williams GV, Goldman-Rakic PS (2000) Destruction and creation of spatial tuning by disinhibition: GABA(A) blockade of prefrontal cortical neurons engaged by working memory. J Neurosci 20:485-94 [PubMed]

Renart A, Song P, Wang XJ (2003) Robust spatial working memory through homeostatic synaptic scaling in heterogeneous cortical networks. Neuron 38:473-85 [PubMed]

Reyes A, Lujan R, Rozov A, Burnashev N, Somogyi P, Sakmann B (1998) Target-cell-specific facilitation and depression in neocortical circuits. Nat Neurosci 1:279-85 [PubMed]

Rhodes P (2006) The properties and implications of NMDA spikes in neocortical pyramidal cells. J Neurosci 26:6704-15 [PubMed]

Sanchez-Vives MV, McCormick DA (2000) Cellular and network mechanisms of rhythmic recurrent activity in neocortex. Nat Neurosci 3:1027-34 [PubMed]

Schiller J, Major G, Koester HJ, Schiller Y (2000) NMDA spikes in basal dendrites of cortical pyramidal neurons. Nature 404:285-9 [PubMed]

Schluppeck D, Curtis CE, Glimcher PW, Heeger DJ (2006) Sustained activity in topographic areas of human posterior parietal cortex during memory-guided saccades. J Neurosci 26:5098-108 [PubMed]

Schluppeck D, Glimcher P, Heeger DJ (2005) Topographic organization for delayed saccades in human posterior parietal cortex. J Neurophysiol 94:1372-84 [Journal] [PubMed]

Segev I (1995) Dendritic processing Brain Theory And Neural Networks, Arbib MA, ed. pp.282

Segev I, Parnas I (1983) Synaptic integration mechanisms. Theoretical and experimental investigation of temporal postsynaptic interactions between excitatory and inhibitory inputs. Biophys J 41:41-50 [PubMed]

Sereno AB, Maunsell JH (1998) Shape selectivity in primate lateral intraparietal cortex. Nature 395:500-3 [PubMed]

Sereno MI, Pitzalis S, Martinez A (2001) Mapping of contralateral space in retinotopic coordinates by a parietal cortical area in humans. Science 294:1350-4 [PubMed]

Shepherd GM, Brayton RK (1987) Logic operations are properties of computer-simulated interactions between excitable dendritic spines. Neuroscience 21:151-65 [Journal] [PubMed]

Shu Y, Hasenstaub A, Badoual M, Bal T, McCormick DA (2003) Barrages of synaptic activity control the gain and sensitivity of cortical neurons. J Neurosci 23:10388-401 [PubMed]

Shu Y, Hasenstaub A, McCormick DA (2003) Turning on and off recurrent balanced cortical activity. Nature 423:288-93 [PubMed]

Silberberg G, Markram H (2007) Disynaptic inhibition between neocortical pyramidal cells mediated by Martinotti cells. Neuron 53:735-46 [PubMed]

   [3 reconstructed morphologies on NeuroMorpho.Org]

Somogyi P, Tamas G, Lujan R, Buhl EH (1998) Salient features of synaptic organisation in the cerebral cortex. Brain Res Brain Res Rev 26:113-35 [PubMed]

Spratling MW, Johnson MH (2001) Dendritic inhibition enhances neural coding properties. Cereb Cortex 11:1144-9 [PubMed]

Spratling MW, Johnson MH (2002) Preintegration lateral inhibition enhances unsupervised learning. Neural Comput 14:2157-79 [PubMed]

Spruston N (2008) Pyramidal neurons: dendritic structure and synaptic integration. Nat Rev Neurosci 9:206-21 [PubMed]

Spruston N, Stuart GJ, Hausser M (2007) Dendritic integration. Dendrites, Ed 2, Stuart GJ:Spruston N:Hausser M, ed. pp.351

Steriade M, Nunez A, Amzica F (1993) 1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components. J Neurosci 13:3252-65 [PubMed]

Tamas G, Buhl EH, Somogyi P (1997) Fast IPSPs elicited via multiple synaptic release sites by different types of GABAergic neurone in the cat visual cortex. J Physiol 500 ( Pt 3):715-38 [PubMed]

Tanaka S (2006) Dopamine controls fundamental cognitive operations of multi-target spatial working memory. Neural Netw 15:573-82 [PubMed]

Tegner J, Compte A, Wang XJ (2002) The dynamical stability of reverberatory neural circuits. Biol Cybern 87:471-81 [PubMed]

Troyer TW, Krukowski AE, Priebe NJ, Miller KD (1998) Contrast-invariant orientation tuning in cat visual cortex: thalamocortical input tuning and correlation-based intracortical connectivity. J Neurosci 18:5908-27 [Journal] [PubMed]

Wang XJ, Tegner J, Constantinidis C, Goldman-Rakic PS (2004) Division of labor among distinct subtypes of inhibitory neurons in a cortical microcircuit of working memory. Proc Natl Acad Sci U S A 101:1368-73 [PubMed]

Behabadi BF, Mel BW (2014) Mechanisms underlying subunit independence in pyramidal neuron dendrites. Proc Natl Acad Sci U S A 111:498-503 [Journal] [PubMed]

   Mechanisms underlying subunit independence in pyramidal neuron dendrites (Behabadi and Mel 2014) [Model]

Behabadi BF, Polsky A, Jadi M, Schiller J, Mel BW (2012) Location-dependent excitatory synaptic interactions in pyramidal neuron dendrites. PLoS Comput Biol 8:e1002599 [Journal] [PubMed]

   Excitatory synaptic interactions in pyramidal neuron dendrites (Behabadi et al. 2012) [Model]

Ferrante M, Migliore M, Ascoli GA (2013) Functional Impact of Dendritic Branch-Point Morphology J. Neurosci. 33:2156-2165 [Journal]

   Functional impact of dendritic branch point morphology (Ferrante et al., 2013) [Model]

Legenstein R, Maass W (2011) Branch-specific plasticity enables self-organization of nonlinear computation in single neurons. J Neurosci 31:10787-802 [Journal] [PubMed]

(104 refs)