Experimental and modeling studies of desensitization of P2X3 receptors (Sokolova et al. 2006)

 Download zip file 
Help downloading and running models
Accession:117691
"The function of ATP-activated P2X3 receptors involved in pain sensation is modulated by desensitization, a phenomenon poorly understood. The present study used patch-clamp recording from cultured rat or mouse sensory neurons and kinetic modeling to clarify the properties of P2X3 receptor desensitization. ... Desensitization properties were well accounted for by a cyclic model in which receptors could be desensitized from either open or closed states. Recovery was assumed to be a multistate process with distinct kinetics dependent on the agonist-dependent dissociation rate from desensitized receptors. ... By using subthreshold concentrations of an HAD (high-affinity desensitization)-potent agonist, it might be possible to generate sustained inhibition of P2X3 receptors for controlling chronic pain."
Reference:
1 . Sokolova E, Skorinkin A, Moiseev I, Agrachev A, Nistri A, Giniatullin R (2006) Experimental and modeling studies of desensitization of P2X3 receptors. Mol Pharmacol 70:373-82 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism:
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s): Sensory Receptors;
Gene(s):
Transmitter(s):
Simulation Environment: Pascal/Delphi;
Model Concept(s): Ion Channel Kinetics; Nociception;
Implementer(s): Skorinkin, Andrei [askorink at yandex.ru];
Search NeuronDB for information about:  Sensory Receptors;
[FileVersion]
Version=6.0
[Compiler]
A=8
B=0
C=1
D=1
E=0
F=0
G=1
H=1
I=1
J=1
K=0
L=1
M=0
N=1
O=1
P=1
Q=0
R=0
S=0
T=0
U=0
V=1
W=0
X=1
Y=1
Z=1
ShowHints=1
ShowWarnings=1
UnitAliases=WinTypes=Windows;WinProcs=Windows;DbiTypes=BDE;DbiProcs=BDE;DbiErrs=BDE;
[Linker]
MapFile=0
OutputObjs=0
ConsoleApp=1
DebugInfo=0
RemoteSymbols=0
MinStackSize=16384
MaxStackSize=1048576
ImageBase=4194304
ExeDescription=
[Directories]
OutputDir=
UnitOutputDir=
PackageDLLOutputDir=
PackageDCPOutputDir=
SearchPath=
Packages=
Conditionals=
DebugSourceDirs=
UsePackages=0
[Parameters]
RunParams=
HostApplication=
Launcher=
UseLauncher=0
DebugCWD=
[Language]
ActiveLang=
ProjectLang=$00000419
RootDir=
[Version Info]
IncludeVerInfo=0
AutoIncBuild=0
MajorVer=1
MinorVer=0
Release=0
Build=0
Debug=0
PreRelease=0
Special=0
Private=0
DLL=0
Locale=1049
CodePage=1251
[Version Info Keys]
CompanyName=
FileDescription=
FileVersion=1.0.0.0
InternalName=
LegalCopyright=
LegalTrademarks=
OriginalFilename=
ProductName=
ProductVersion=1.0.0.0
Comments=

Loading data, please wait...