Ca3 pyramidal neuron: membrane response near rest (Hemond et al. 2009)

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Accession:118098
In this paper, the model was used to show how the temporal summation of excitatory inputs in CA3 pyramidal neurons was affected by the presence of Ih in the dendrites in a frequency- and distance-dependent fashion.
Reference:
1 . Hemond P, Migliore M, Ascoli GA, Jaffe DB (2009) The membrane response of hippocampal CA3b pyramidal neurons near rest: heterogeneity of passive properties and the contribution of hyperpolarization-activated currents. Neuroscience 160(2):359-370 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Dendrite;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal cell;
Channel(s): I h;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Synaptic Integration;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal cell; AMPA; I h; Glutamate;
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ca3-summ
readme.txt
distr.mod *
hca3.mod
fig-8b.hoc
fixnseg.hoc *
geo-cell1zr.hoc *
mosinit.hoc
                            
NEURON mod files from the paper:
The membrane response of hippocampal CA3b pyramidal neurons near rest: 
heterogeneity of passive properties and the contribution of hyperpolarization-activated 
currents, by P. Hemond, M. Migliore, GA Ascoli, and DB Jaffe, Neuroscience, in press (2009).

The simulation file can be used to generate the raw data for the bottom plot in Fig.8b,
showing the normalized peak somatic summation, with or without Ih, in response 
to a train of EPSPs at 50Hz

Questions on how to use this model
should be directed to michele.migliore@pa.ibf.cnr.it



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