Tag Trigger Consolidation (Clopath and Ziegler et al. 2008)

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Accession:118199
This model simulates different phases of LTP/D, i.e. the induction or early phase, the setting of synaptic tags, a trigger process for protein synthesis, and a slow transition leading to synaptic consolidation namely the late phase of synaptic plasticity. The model explains a large body of experimental data on synaptic tagging and capture, cross-tagging, and the late phases of LTP and LTD. Moreover, the model accounts for the dependence of LTP and LTD induction on voltage and presynaptic stimulation frequency.
Reference:
1 . Clopath C, Ziegler L, Vasilaki E, B├╝sing L, Gerstner W (2008) Tag-trigger-consolidation: a model of early and late long-term-potentiation and depression. PLoS Comput Biol 4:e1000248 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Synapse;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Abstract integrate-and-fire adaptive exponential (AdEx) neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Dopamine;
Simulation Environment: Python;
Model Concept(s): Simplified Models; Synaptic Plasticity; Long-term Synaptic Plasticity; Maintenance;
Implementer(s): Ziegler, Lorric ;
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; Dopamine;
 
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