Calyx of Held, short term plasticity (Yang Z et al. 2009)

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Accession:118554
This model investigates mechanisms contributing to short term plasticity at the calyx of Held, a giant glutamatergic synapse in the mammalian brainstem auditory system. It is a stochastic version of the model described in: Hennig, M., Postlethwaite, M., Forsythe, I.D. and Graham, B.P. (2007). A biophysical model of short-term plasticity at the calyx of Held. Neurocomputing, 70:1626-1629. This version introduces stochastic vesicle recycling and release. It has been used to investigate the information transmission properties of this synapse, as detailed in: Yang, Z., Hennig, M., Postlethwaite, M., Forsythe, I.D. and Graham, B.P. (2008). Wide-band information transmission at the calyx of Held. Neural Computation, 21(4):991-1018.
References:
1 . Yang Z, Hennig MH, Postlethwaite M, Forsythe ID, Graham BP (2009) Wide-band information transmission at the calyx of Held. Neural Comput 21:991-1017 [PubMed]
2 . Hennig MH, Postlethwaite M, Forsythe ID, Graham BP (2007) A biophysical model of short-term plasticity at the calyx of Held, Neurocomputing 70(12):1626-1629
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism: Auditory brainstem;
Cell Type(s): Medial Nucleus of the Trapezoid Body (MNTB) neuron;
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: MATLAB;
Model Concept(s): Short-term Synaptic Plasticity; Vestibular;
Implementer(s): Hennig, Matthias H [mhhennig at gmail.com];
Search NeuronDB for information about:  Glutamate;
0.05	100	0
0.1	66.51994323	4.154337553
0.15	49.34452106	3.668592686
0.2	44.56894647	3.104654695
0.25	38.61515316	3.284777949
0.3	36.11436675	2.809775356
0.35	34.29188089	2.647005989
0.4	32.34544429	2.587139539
0.45	31.31330835	2.81988065
0.5	30.40155814	2.269424111
0.55	30.44210253	2.582557236
0.6	28.99997426	2.673719614
0.65	28.90201149	2.27331738
0.7	27.70180295	2.336933989
0.75	28.40085144	2.6037755
0.8	27.79830162	2.672848847
0.85	28.05479748	2.353541857
0.9	28.50019768	2.668645357
0.95	27.1980687	2.384300867
1	27.75058578	2.525895375

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