Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)

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Accession:119266
"We use a multi-compartmental model of a CA1 pyramidal cell to study changes in hippocampal excitability that result from aging-induced alterations in calcium-dependent membrane mechanisms. The model incorporates N- and L-type calcium channels which are respectively coupled to fast and slow afterhyperpolarization potassium channels. Model parameters are calibrated using physiological data. Computer simulations reproduce the decreased excitability of aged CA1 cells, which results from increased internal calcium accumulation, subsequently larger postburst slow afterhyperpolarization, and enhanced spike frequency adaptation. We find that aging-induced alterations in CA1 excitability can be modelled with simple coupling mechanisms that selectively link specific types of calcium channels to specific calcium-dependent potassium channels."
Reference:
1 . Markaki M, Orphanoudakis S, Poirazi P (2005) Modelling reduced excitability in aged CA1 neurons as a calcium-dependent process Neurocomputing 65-66:305-314
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I N; I A; I K; I M; I K,Ca; I R;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Aging/Alzheimer`s;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I Na,p; I Na,t; I L high threshold; I N; I A; I K; I M; I K,Ca; I R;
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CA1_Aged
morphology
n123
apical-non-trunk-list.hoc *
apical-tip-list.hoc *
apical-tip-list-addendum.hoc *
apical-trunk-list.hoc *
axon-sec-list.hoc *
basal-paths.hoc *
basal-tree-list.hoc *
cell.hoc *
cell-analysis.hoc *
gabab-gabaa-uniform-ratio.hoc *
n123.hoc *
nmda-ampa-ratio.hoc *
oblique-paths.hoc *
peri-trunk-list.hoc *
soma-list.hoc *
                            
// This function makes a list with oblique branches in addition to 
// the primary list in apical-tip-list.hoc 
// written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu

objref apical_tip_list_addendum
apical_tip_list_addendum=new SectionList()


//    SISTER of apical_dendrite[3]   is apical_dendrite[2]    
//    SISTER of apical_dendrite[34]  is apical_dendrite[33]   
//    SISTER of apical_dendrite[37]  is apical_dendrite[36]   
//    SISTER of apical_dendrite[40]  is apical_dendrite[39]
//    SISTER of apical_dendrite[45]  is apical_dendrite[44]
//    SISTER of apical_dendrite[54]  is apical_dendrite[53] 
//    SISTER of apical_dendrite[68]  is apical_dendrite[67] 
//    SISTER of apical_dendrite[111] is apical_dendrite[110] 
//    SISTER of apical_dendrite[115] is apical_dendrite[114] 
//    SISTER of apical_dendrite[118] is apical_dendrite[117] 

  apical_dendrite[2]    apical_tip_list_addendum.append()  // 1 degree      69.9821  microns from soma
  apical_dendrite[33]   apical_tip_list_addendum.append()  // 2 degrees    177.4831 (vertical distance)
  apical_dendrite[36]   apical_tip_list_addendum.append()  // 2 degree     189.0447 
  apical_dendrite[37]   apical_tip_list_addendum.append()  // 2 degrees    180.5792 
  apical_dendrite[39]   apical_tip_list_addendum.append()  // 1 degree      83.7030
  apical_dendrite[40]   apical_tip_list_addendum.append()  // 1 degreee    102.6654
  apical_dendrite[44]   apical_tip_list_addendum.append()  // 0 degree     172.7760 
  apical_dendrite[47]   apical_tip_list_addendum.append()  // 0 degree.    177.4980
  apical_dendrite[53]   apical_tip_list_addendum.append()  // 3 degrees    202.8910
  apical_dendrite[54]   apical_tip_list_addendum.append()  // 3 degrees    190.3009
  apical_dendrite[67]   apical_tip_list_addendum.append()  // 2 degrees    289.5367   
  apical_dendrite[110]  apical_tip_list_addendum.append()  // 1 degree      98.7392
  apical_dendrite[114]  apical_tip_list_addendum.append()  // 1 degree     123.9962
  apical_dendrite[117]  apical_tip_list_addendum.append()  // 0 degree      67.6363

//  forsec apical_tip_list_addendum {
//    apical_tip_list.append()
//  }

/* Make a shape graph with the additional oblique branches

objref apical_tip_list_addendum_shape
color_index = 3
apical_tip_list_addendum_shape=new Shape()
apical_tip_list_addendum_shape.color_list(apical_tip_list_addendum,color_index)
apical_tip_list_addendum_shape.printfile("apical-tip-list-addendum.eps")
*/

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