Modelling reduced excitability in aged CA1 neurons as a Ca-dependent process (Markaki et al. 2005)

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Accession:119266
"We use a multi-compartmental model of a CA1 pyramidal cell to study changes in hippocampal excitability that result from aging-induced alterations in calcium-dependent membrane mechanisms. The model incorporates N- and L-type calcium channels which are respectively coupled to fast and slow afterhyperpolarization potassium channels. Model parameters are calibrated using physiological data. Computer simulations reproduce the decreased excitability of aged CA1 cells, which results from increased internal calcium accumulation, subsequently larger postburst slow afterhyperpolarization, and enhanced spike frequency adaptation. We find that aging-induced alterations in CA1 excitability can be modelled with simple coupling mechanisms that selectively link specific types of calcium channels to specific calcium-dependent potassium channels."
Reference:
1 . Markaki M, Orphanoudakis S, Poirazi P (2005) Modelling reduced excitability in aged CA1 neurons as a calcium-dependent process Neurocomputing 65-66:305-314
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA1 pyramidal GLU cell;
Channel(s): I Na,p; I Na,t; I L high threshold; I N; I A; I K; I M; I K,Ca; I R;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Aging/Alzheimer`s;
Implementer(s):
Search NeuronDB for information about:  Hippocampus CA1 pyramidal GLU cell; I Na,p; I Na,t; I L high threshold; I N; I A; I K; I M; I K,Ca; I R;
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CA1_Aged
morphology
n123
apical-non-trunk-list.hoc *
apical-tip-list.hoc *
apical-tip-list-addendum.hoc *
apical-trunk-list.hoc *
axon-sec-list.hoc *
basal-paths.hoc *
basal-tree-list.hoc *
cell.hoc *
cell-analysis.hoc *
gabab-gabaa-uniform-ratio.hoc *
n123.hoc *
nmda-ampa-ratio.hoc *
oblique-paths.hoc *
peri-trunk-list.hoc *
soma-list.hoc *
                            
// This function makes a list with primary oblique dendrites
// written by Yiota Poirazi, July 2001, poirazi@LNC.usc.edu

objref apical_tip_list
apical_tip_list=new SectionList()

// List of obliques located at distances approximatelly less than 300 microns from the soma

proc proximals() {

  apical_dendrite[3]    apical_tip_list.append()   // 1 degree                 74.4  microns from soma
  apical_dendrite[5]    apical_tip_list.append()   // 0 degree                 57.46 (vertical distance)
  apical_dendrite[24]   apical_tip_list.append()   // 0 degree                 92.05
  apical_dendrite[30]   apical_tip_list.append()   // 0 degree  (essentially) 153.44
  apical_dendrite[34]   apical_tip_list.append()   // 2 degrees (ignore 3rd)  215.06
  apical_dendrite[45]   apical_tip_list.append()   // 0 degree. (essentially) 170.32
  apical_dendrite[51]   apical_tip_list.append()   // 2 degrees               210.93
  apical_dendrite[59]   apical_tip_list.append()   //                         189.34
  apical_dendrite[61]   apical_tip_list.append()   //                         221.55
  apical_dendrite[63]   apical_tip_list.append()   //                         231.58
  apical_dendrite[68]   apical_tip_list.append()   // 2 degrees               277.48
  apical_dendrite[70]   apical_tip_list.append()   // 0 degree                300.94
  apical_dendrite[106]  apical_tip_list.append()   // 0 degree                258.05
  apical_dendrite[107]  apical_tip_list.append()   // 0 degree                159.55      
  apical_dendrite[111]  apical_tip_list.append()   // 1 degree                106.30
  apical_dendrite[112]  apical_tip_list.append()   // 0 degree                 88.52
  apical_dendrite[115]  apical_tip_list.append()   // 1 degree                117.79
  apical_dendrite[118]  apical_tip_list.append()   // 0 degree                 81.66
}

// List of obliques located beyond 300 microns from the soma

proc distals() {    
  apical_dendrite[73]   apical_tip_list.append()   // 0 degree                334.84 
  apical_dendrite[82]   apical_tip_list.append()   // 0 degree                360.28
  apical_dendrite[86]   apical_tip_list.append()   // 0 degree                419.68
  apical_dendrite[93]   apical_tip_list.append()   // 0 degree                468.60
  apical_dendrite[97]   apical_tip_list.append()   // 0 degree                445.90
  apical_dendrite[105]  apical_tip_list.append()   // 0 degree                425.58
}

proximals()
distals()

/* Make a shape graph with apical oblique dendrites
objref apical_tip_list_shape
color_index = 2
apical_tip_list_shape=new Shape()
apical_tip_list_shape.color_list(apical_tip_list,color_index)
apical_tip_list_shape.action("secname()")
apical_tip_list_shape.printfile("apical-tip-list.eps")
*/

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