A kinetic model unifying presynaptic short-term facilitation and depression (Lee et al. 2009)

 Download zip file 
Help downloading and running models
Accession:120184
"... Here, we propose a unified theory of synaptic short-term plasticity based on realistic yet tractable and testable model descriptions of the underlying intracellular biochemical processes. Analysis of the model equations leads to a closed-form solution of the resonance frequency, a function of several critical biophysical parameters, as the single key indicator of the propensity for synaptic facilitation or depression under repetitive stimuli. This integrative model is supported by a broad range of transient and frequency response experimental data including those from facilitating, depressing or mixed-mode synapses. ... the model provides the reasons behind the switching behavior between facilitation and depression observed in experiments. ..."
Reference:
1 . Lee CC, Anton M, Poon CS, McRae GJ (2009) A kinetic model unifying presynaptic short-term facilitation and depression. J Comput Neurosci 26:459-73 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell; Cerebellum Purkinje cell; Auditory nerve;
Channel(s): I Calcium;
Gap Junctions:
Receptor(s): AMPA;
Gene(s):
Transmitter(s): Glutamate;
Simulation Environment: MATLAB; Simulink;
Model Concept(s): Synaptic Plasticity; Facilitation; Depression; Calcium dynamics;
Implementer(s): Lee, Chuang-Chung [chchlee at alum.mit.edu]; Anton, Mihai [mianton at mit.edu]; Poon, Chi-Sang [cpoon at mit.edu]; McRae, Gregory [mcrae at mit.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; Cerebellum Purkinje cell; AMPA; I Calcium; Glutamate;
Loading data, please wait...