Here, we propose a unified theory of synaptic short-term plasticity based on realistic yet tractable and testable model descriptions of the underlying intracellular biochemical processes.
Analysis of the model equations leads to a closed-form solution of the resonance frequency, a function of several critical biophysical parameters, as the single key indicator of the propensity for synaptic facilitation or depression under repetitive stimuli.
This integrative model is supported by a broad range of transient and frequency response experimental data including those from facilitating, depressing or mixed-mode synapses.
... the model provides the reasons behind the switching behavior between facilitation and depression observed in experiments. ..."
Lee CC, Anton M, Poon CS, McRae GJ (2009) A kinetic model unifying presynaptic short-term facilitation and depression. J Comput Neurosci 26:459-73 [PubMed]