Thalamic neuron: Modeling rhythmic neuronal activity (Meuth et al. 2005)

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Accession:121600
The authors use an in vitro cell model of a single acutely isolated thalamic neuron in the NEURON simulation environment to address and discuss questions in an undergraduate course. Topics covered include passive electrical properties, composition of action potentials, trains of action potentials, multicompartment modeling, and research topics. The paper includes detailed instructions on how to run the simulations in the appendix.
Reference:
1 . Meuth P, Meuth SG, Jacobi D, Broicher T, Pape HC, Budde T (2005) Get the rhythm: modeling neuronal activity. J Undergrad Neurosci Educ 4:A1-A11 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Tutorial/Teaching; Action Potentials;
Implementer(s):
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal GLU cell; I Na,t; I L high threshold; I T low threshold; I A; I K; I h;
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MeuthEtAl2005_local
model
4
HH.mod *
HH.mod.orig
ia.mod *
ic.mod *
ih.mod *
il.mod *
inap.mod *
it.mod *
leak.mod *
Exp4.ses
Neuron.hoc
Neuron.hoc.bak
                            
load_file("nrngui.hoc")
v_init = -70
tstop = 500

create soma	
access soma	

{L = 30 diam = 20} 
  
insert leak
insert HH
insert iA
insert iC
insert iH
insert iT
insert iNaP
insert iL


celsius = 35

nao = 145 
{ki = 135 ko = 3.1}
{cli = 7 clo = 120}

pk_leak=8e-6
gkbar_iA=0.0055
gkbar_iC=0.00018
ghbar_iH=0.0006
eh= -40
pcabar_iT=0.00045
g_iNaP=17e-5


objref stimulus
stimulus = new IClamp(0.5)
stimulus.amp = 0.2
stimulus.del = 100
stimulus.dur = 100

psection()


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