Thalamic neuron: Modeling rhythmic neuronal activity (Meuth et al. 2005)

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Accession:121600
The authors use an in vitro cell model of a single acutely isolated thalamic neuron in the NEURON simulation environment to address and discuss questions in an undergraduate course. Topics covered include passive electrical properties, composition of action potentials, trains of action potentials, multicompartment modeling, and research topics. The paper includes detailed instructions on how to run the simulations in the appendix.
Reference:
1 . Meuth P, Meuth SG, Jacobi D, Broicher T, Pape HC, Budde T (2005) Get the rhythm: modeling neuronal activity. J Undergrad Neurosci Educ 4:A1-A11 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Thalamus geniculate nucleus/lateral principal neuron;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Tutorial/Teaching; Action Potentials;
Implementer(s):
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal neuron; I Na,t; I L high threshold; I T low threshold; I A; I K; I h;
TITLE passive sodium, potassium, calcium, chloride and magnesium channels

COMMENT
        Assembled for MyFirstNEURON by Arthur Houweling
ENDCOMMENT

INDEPENDENT { t FROM 0 TO 1 WITH 1 (ms) }

UNITS {
	(mV) = (millivolt)
	(mA) = (milliamp)
	(mM) = (milli/liter)
        FARADAY = 96480 (coul)
        R       = 8.314 (volt-coul/degC)
}

NEURON {
	SUFFIX leak
	USEION na READ nai,nao WRITE ina
	USEION k READ ki,ko WRITE ik
	USEION ca READ cai,cao WRITE ica
        USEION cl READ cli,clo WRITE icl VALENCE 1 
	: negative valence not accepted
	: if 'ecl' is needed in a MOD-file use '-ecl' instead
        USEION mg READ mgi,mgo WRITE img VALENCE 2
	RANGE pna,pk,pca,pcl,pmg,ina,ik,ica,icl,img
}

PARAMETER {
	v		(mV)	
        celsius		(degC)
	nai		(mM)
	nao		(mM)
	pna= 2.07e-7	(cm/s)
        ki      	(mM)
        ko      	(mM)
        pk= 3.45e-6	(cm/s)
        cai     	(mM)
        cao     	(mM)
        pca= 0		(cm/s)
        cli     	(mM)
        clo     	(mM)
        pcl= 0		(cm/s)
        mgi     	(mM)
        mgo     	(mM)
        pmg= 0		(cm/s)
}

ASSIGNED {
	ina	(mA/cm2)
	ik      (mA/cm2)
	ica	(mA/cm2)
        icl     (mA/cm2)
	img	(mA/cm2)
}

BREAKPOINT {
	ina = pna * ghk(v,nai,nao,1)
        ik = pk * ghk(v,ki,ko,1)
        ica = pca * ghk(v,cai,cao,2)
        icl = pcl * ghk(v,cli,clo,-1)
        img = pmg * ghk(v,mgi,mgo,2)
}

FUNCTION ghk( v(mV), ci(mM), co(mM), z)  (millicoul/cm3) { LOCAL e, w
        w = v * (.001) * z*FARADAY / (R*(celsius+273.16))
        if (fabs(w)>1e-4) 
          { e = w / (exp(w)-1) }
        else 
	: denominator is small -> Taylor series
          { e = 1-w/2 }
        ghk = - (.001) * z*FARADAY * (co-ci*exp(w)) * e
}


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