Thalamic neuron: Modeling rhythmic neuronal activity (Meuth et al. 2005)

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Accession:121600
The authors use an in vitro cell model of a single acutely isolated thalamic neuron in the NEURON simulation environment to address and discuss questions in an undergraduate course. Topics covered include passive electrical properties, composition of action potentials, trains of action potentials, multicompartment modeling, and research topics. The paper includes detailed instructions on how to run the simulations in the appendix.
Reference:
1 . Meuth P, Meuth SG, Jacobi D, Broicher T, Pape HC, Budde T (2005) Get the rhythm: modeling neuronal activity. J Undergrad Neurosci Educ 4:A1-A11 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism:
Cell Type(s): Thalamus geniculate nucleus/lateral principal neuron;
Channel(s): I Na,t; I L high threshold; I T low threshold; I A; I K; I h;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Bursting; Tutorial/Teaching; Action Potentials;
Implementer(s):
Search NeuronDB for information about:  Thalamus geniculate nucleus/lateral principal neuron; I Na,t; I L high threshold; I T low threshold; I A; I K; I h;
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MeuthEtAl2005_local
model
mechanism
HH.mod *
ia.mod *
ic.mod *
ih.mod *
il.mod *
inap.mod *
it.mod *
leak.mod *
                            
TITLE transient potassium current (A-current)

COMMENT
	*********************************************
	reference:	Huguenard & McCormick (1992) 
			J.Neurophysiology 68(4), 1373-1383
	found in:	thalamic relay neurons		 	
	*********************************************
	Original by Alain Destexhe
	Rewritten for MyFirstNEURON by Arthur Houweling
ENDCOMMENT

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

NEURON {
	SUFFIX iA
	USEION k READ ek WRITE ik 
        RANGE gkbar, m_inf1, tau_m, h_inf, tau_h1, ik
}

UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
}

PARAMETER {
	v		(mV)
	celsius		(degC)
	dt		(ms)
	ek		(mV)
	gkbar= 0.00345	(mho/cm2)
}

STATE {
	m1 h1
}

ASSIGNED {
	ik		(mA/cm2)
	m_inf1
	tau_m		(ms)
	h_inf
	tau_h1		(ms)
	tadj
}

BREAKPOINT { 
	SOLVE states :METHOD euler
 	ik = gkbar * m1^4*h1 * (v-ek)
}

:DERIVATIVE states { 
:	evaluate_fct(v)
:
:	m1'= (m_inf1-m1) / tau_m
:	h1'= (h_inf-h1) / tau_h1
:}

PROCEDURE states() {
        evaluate_fct(v)

	m1= m1 + (1-exp(-dt/tau_m))*(m_inf1-m1)
	h1= h1 + (1-exp(-dt/tau_h1))*(h_inf-h1)
}

UNITSOFF
INITIAL {
	tadj = 3^((celsius-23.5)/10)
	evaluate_fct(v)
	m1 = m_inf1
        h1 = h_inf
}

PROCEDURE evaluate_fct(v(mV)) {  LOCAL a,b
	tau_m = 1.0/((exp((v+35.82)/19.69)+exp(-(v+79.69)/12.7))+0.37) / tadj
	m_inf1 = 1.0 / (1+exp(-(v+60)/8.5))
	a = 1.0/((exp((v+46.05)/5)+exp(-(v+238.4)/37.45))) / tadj
	if (v<-63) {
		tau_h1 = a
		}
	else {
		tau_h1 = 19.0/tadj
		}
	h_inf = 1.0/(1+exp((v+78)/6))
}
UNITSON

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