" ... In numerical simulations, the availability of both Na+ and A-type K+ channels during autonomous firing were reduced when SK channels were removed, and a nearly equal reduction in Na+ and K+ subthreshold-activated ion channel availability produced a large decrease in the neuron's slope conductance near threshold.
This change made the neuron more sensitive to intrinsically generated noise.
In vivo, this change would also enhance the sensitivity of GP (Globus Pallidus) neurons to small synaptic inputs."
Deister CA, Chan CS, Surmeier DJ, Wilson CJ (2009) Calcium-activated SK channels influence voltage-gated ion channels to determine the precision of firing in globus pallidus neurons. J Neurosci 29:8452-61 [PubMed]