Tight junction model of CNS myelinated axons (Devaux and Gow 2008)

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Accession:122442
Two models are included: 1) a myelinated axon is represented by an equivalent circuit with a double cable design but includes a tight junction in parallel with the myelin membrane RC circuit (called double cable model, DCM). 2) a myelinated axon is represented by an equivalent circuit with a double cable design but includes a tight junction in series with the myelin RC circuit (called tight junction model, TJM). These models have been used to simulate data from compound action potentials measured in mouse optic nerve from Claudin 11-null mice in Fig. 6 of: Devaux, J.J. & Gow, A. (2008) Tight Junctions Potentiate The Insulative Properties Of Small CNS Myelinated Axons. J Cell Biol 183, 909-921.
References:
1 . Devaux J, Gow A (2008) Tight junctions potentiate the insulative properties of small CNS myelinated axons. J Cell Biol 183:909-21 [PubMed]
2 . Gow A, Devaux J (2008) A model of tight junction function in central nervous system myelinated axons. Neuron Glia Biol 4:307-17 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Glia;
Brain Region(s)/Organism: Unknown;
Cell Type(s): Myelinated neuron;
Channel(s): I Na,t; I K; I K,leak; I M;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Axonal Action Potentials;
Implementer(s):
Search NeuronDB for information about:  I Na,t; I K; I K,leak; I M;
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