Na channel mutations in the dentate gyrus (Thomas et al. 2009)

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Accession:123848
These are source files to generate the data in Figure 6 from "Mossy fiber sprouting interacts with sodium channel mutations to increase dentate gyrus excitability" Thomas EA, Reid CA, Petrou S, Epilepsia (2009)
Reference:
1 . Thomas EA, Reid CA, Petrou S (2009) Mossy fiber sprouting interacts with sodium channel mutations to increase dentate gyrus excitability. Epilepsia [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Dentate gyrus granule cell; Dentate gyrus mossy cell; Dentate gyrus basket cell; Dentate gyrus hilar cell;
Channel(s): I Na,t; I A; I K; I K,leak; I K,Ca; I Calcium;
Gap Junctions:
Receptor(s): GabaA; AMPA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: parplex;
Model Concept(s): Ion Channel Kinetics; Epilepsy;
Implementer(s): Thomas, Evan [evan at evan-thomas.net];
Search NeuronDB for information about:  Dentate gyrus granule cell; GabaA; AMPA; I Na,t; I A; I K; I K,leak; I K,Ca; I Calcium; Gaba; Glutamate;
These are source files to generate the data in Figure 6 from
"Mossy fiber sprouting interacts with sodium channel
mutations to increase dentate gyrus excitability" Thomas EA, Reid CA, Petrou S,
Epilepsia (2009)

Intructions:
1) Build and install parplex (see Readme in the parplex directory)
2) python aradi.py
3) python mkdll.py Exp2Syn.c
4) python fig6.py

This will produce a number of ap*.dat. The columns of these files are:
Cellno APtime Celltype. You can use the enclosed Matlab scripts to plot them.

Any questions? Email me evan@evan-thomas.net.



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