Epilepsy may be caused by very small functional changes in ion channels (Thomas et al. 2009)

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Accession:124392
We used a previously published model of the dentate gyrus with varying degrees of mossy fibre sprouting.We preformed a sensitivity analysis where we systematically varied individual properties of ion channels. The results predict that genetic variations in the properties of sodium channels are likely to have the biggest impact on network excitability. Furthermore, these changes may be as small as 1mV, which is currently undetectable using standard experimental practices.
Reference:
1 . Thomas EA, Reid CA, Berkovic SF, Petrou S (2009) Prediction by Modeling That Epilepsy May Be Caused by Very Small Functional Changes in Ion Channels Arch Neurol. 66(10):1225-1232 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism:
Cell Type(s): Dentate gyrus granule cell; Dentate gyrus mossy cell; Dentate gyrus basket cell; Dentate gyrus hilar cell;
Channel(s): I A; I K; I K,leak; I Sodium; I Calcium;
Gap Junctions:
Receptor(s): GabaA; AMPA;
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: parplex;
Model Concept(s): Epilepsy;
Implementer(s): Thomas, Evan [evan at evan-thomas.net];
Search NeuronDB for information about:  Dentate gyrus granule cell; GabaA; AMPA; I A; I K; I K,leak; I Sodium; I Calcium; Gaba; Glutamate;
These are source files to generate the data in Figure 5 from
"Modeling predicts that epilepsy may be caused by very small functional changes 
in ion channels" Thomas EA, Reid CA, Petrou S, Archives of Neurology (2009)

Intructions:
1) Build and install parplex (see Readme in the parplex directory)
2) python aradi.py
3) python mkdll.py Exp2Syn.c
4) python fig6.py

This will produce a number of ap*.dat. The columns of these files are:
Cellno APtime Celltype. You can use the enclosed Matlab scripts to plot them.

Any questions? Email me evan@evan-thomas.net.



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