Dendritic Na+ spike initiation and backpropagation of APs in active dendrites (Nevian et al. 2007)

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Accession:124394
NEURON model used to create simulations shown in figure 6 of the paper. The model includes two point processes; one for dendritic spike initiation and the other for somatic action potential generation. The effect of filtering by imperfect recording electrode can be examined in somatic and dendritic locations.
Reference:
1 . Nevian T, Larkum ME, Polsky A, Schiller J (2007) Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study. Nat Neurosci 10:206-14 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell;
Brain Region(s)/Organism: Neocortex;
Cell Type(s): Neocortex V1 L6 pyramidal corticothalamic GLU cell;
Channel(s): I N; I K;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models;
Implementer(s): Polsky, Alon [alonpol at tx.technion.ac.il];
Search NeuronDB for information about:  Neocortex V1 L6 pyramidal corticothalamic GLU cell; I N; I K;
load_file("11_12.hoc")//the cell

forall {
	nseg=9
	insert pas
	e_pas=-60

	g_pas=0.00005

	cm=2
}
forsec basal {nseg=9 diam=diam*1.5}

dend[56].nseg=17
dend[49].nseg=9



//load_file("11_12.ses")//the cell
load_file("basal.ses")

forall{
	insert hh3
	gnabar_hh3=0.12
	gkbar_hh3=0.003

	l_hh3=0
}

ena=70
taus_hh3=30
tausv_hh3=10
tausn_hh3=5
tausb_hh3=0.1
taun_hh3=.5
forsec somatic {
	nseg=9
	gnabar_hh3=1
	gkbar_hh3=0.01
}
axon{
	nseg=9
	gnabar_hh3=10
}

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