Availability of low-threshold Ca2+ current in retinal ganglion cells (Lee SC et al. 2003)

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Accession:125378
"... we measured T-type current of isolated goldfish retinal ganglion cells with perforated-patch voltageclamp methods in solutions containing a normal extracellular Ca2+ concentration. The voltage sensitivities and rates of current activation, inactivation, deactivation, and recovery from inactivation were similar to those of expressed +1G (CaV3.1) Ca2+ channel clones, except that the rate of deactivation was significantly faster. We reproduced the amplitude and kinetics of measured T currents with a numerical simulation based on a kinetic model developed for an +1G Ca2+ channel. Finally, we show that this model predicts the increase of T-type current made available between resting potential and spike threshold by repetitive hyperpolarizations presented at rates that are within the bandwidth of signals processed in situ by these neurons."
Reference:
1 . Lee SC, Hayashida Y, Ishida AT (2003) Availability of Low-Threshold Ca2+ Current in Retinal Ganglion Cells J Neurophysiol 90:3888-3901 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Channel/Receptor;
Brain Region(s)/Organism: Retina;
Cell Type(s): Retina ganglion cell;
Channel(s): I T low threshold;
Gap Junctions:
Receptor(s):
Gene(s): Cav3.1 CACNA1G;
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Ion Channel Kinetics;
Implementer(s): Hayashida, Yuki [yukih at cs.kumamoto-u.ac.jp];
Search NeuronDB for information about:  Retina ganglion cell; I T low threshold;
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leeEtAl2003
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