Spike propagation in dendrites with stochastic ion channels (Diba et al. 2006)

 Download zip file   Auto-launch 
Help downloading and running models
Accession:125385
"We investigate the effects of the stochastic nature of ion channels on the faithfulness, precision and reproducibility of electrical signal transmission in weakly active, dendritic membrane under in vitro conditions. ... We numerically simulate the effects of stochastic ion channels on the forward and backward propagation of dendritic spikes in Monte-Carlo simulations on a reconstructed layer 5 pyramidal neuron. We report that in most instances there is little variation in timing or amplitude for a single BPAP, while variable backpropagation can occur for trains of action potentials. Additionally, we find that the generation and forward propagation of dendritic Ca2+ spikes are susceptible to channel variability. This indicates limitations on computations that depend on the precise timing of Ca2+ spikes."
Reference:
1 . Diba K, Koch C, Segev I (2006) Spike propagation in dendrites with stochastic ion channels J Comput Neurosci 20:77-84 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Channel/Receptor;
Brain Region(s)/Organism: Neocortex;
Cell Type(s):
Channel(s):
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Active Dendrites; Action Potentials;
Implementer(s): Diba, Kamran [diba at andromeda.rutgers.edu];
/
Sbpap_code
mod
readme.html
BACModel.hoc
BACpna.hoc
d980329a-1.nrn *
Display2.ses
init.hoc
mosinit.hoc *
                            
load_file("nrngui.hoc")
load_file("init.hoc")

Diba K, Koch C, Segev I (2006) Spike propagation in dendrites with stochastic ion channels J Comput Neurosci 20:77-84[PubMed]

References and models cited by this paper

References and models that cite this paper

Ariav G, Polsky A, Schiller J (2003) Submillisecond precision of the input-output transformation function mediated by fast sodium dendritic spikes in basal dendrites of CA1 pyramidal neurons. J Neurosci 23:7750-8 [PubMed]

Bernard C, Johnston D (2003) Distance-dependent modifiable threshold for action potential back-propagation in hippocampal dendrites. J Neurophysiol 90:1807-16 [Journal] [PubMed]

Buzsaki G, Penttonen M, Nadasdy Z, Bragin A (1996) Pattern and inhibition-dependent invasion of pyramidal cell dendrites by fast spikes in the hippocampus in vivo. Proc Natl Acad Sci U S A 93:9921-5 [PubMed]

Chow CC, White JA (1996) Spontaneous action potentials due to channel fluctuations. Biophys J 71:3013-21 [PubMed]

   Spontaneous firing caused by stochastic channel gating (Chow, White 1996) [Model]

Colbert CM, Magee JC, Hoffman DA, Johnston D (1997) Slow recovery from inactivation of Na+ channels underlies the activity-dependent attenuation of dendritic action potentials in hippocampal CA1 pyramidal neurons. J Neurosci 17:6512-21 [PubMed]

Debanne D (2004) Information processing in the axon. Nat Rev Neurosci 5:304-16 [PubMed]

Defelice LJ (1981) Introduction to Membrane Noise

Destexhe A, Rudolph M, Pare D (2003) The high-conductance state of neocortical neurons in vivo. Nat Rev Neurosci 4:739-51 [PubMed]

Diba K, Lester HA, Koch C (2004) Intrinsic noise in cultured hippocampal neurons: experiment and modeling. J Neurosci 24:9723-33 [PubMed]

Faisal AA, Laughlin SB (2002) Channel noise limits the minimum diameter of axons J Physiol Lond 543:21

Golding NL, Kath WL, Spruston N (2001) Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites. J Neurophysiol 86:2998-3010 [Journal] [PubMed]

   [22 reconstructed morphologies on NeuroMorpho.Org]
   Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites (Golding et al 2001) [Model]

Golding NL, Spruston N (1998) Dendritic sodium spikes are variable triggers of axonal action potentials in hippocampal CA1 pyramidal neurons. Neuron 21:1189-200 [PubMed]

Hille B (2001) Classic mechanisms of block Ion Channels of Excitable Membranes (3rd edn) :503-537

Hines ML, Carnevale NT (1997) The NEURON simulation environment. Neural Comput 9:1179-209 [PubMed]

Hodgkin AL, Huxley AF (1952) A quantitative description of membrane current and its application to conduction and excitation in nerve. J Physiol 117:500-44 [Journal] [PubMed]

   Squid axon (Hodgkin, Huxley 1952) (LabAXON) [Model]
   Squid axon (Hodgkin, Huxley 1952) (NEURON) [Model]
   Squid axon (Hodgkin, Huxley 1952) (SNNAP) [Model]
   Squid axon (Hodgkin, Huxley 1952) used in (Chen et al 2010) (R language) [Model]
   Squid axon (Hodgkin, Huxley 1952) (SBML, XPP, other) [Model]

Hoffman DA, Magee JC, Colbert CM, Johnston D (1997) K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature 387:869-75 [PubMed]

Horikawa Y (1991) Noise effects on spike propagation in the stochastic Hodgkin-Huxley models. Biol Cybern 66:19-25 [PubMed]

Horikawa Y (1993) Simulation study on effects of channel noise on differential conduction at an axon branch. Biophys J 65:680-6

Jacobson GA, Diba K, Yaron-Jakoubovitch A, Oz Y, Koch C, Segev I, Yarom Y (2005) Subthreshold voltage noise of rat neocortical pyramidal neurones. J Physiol 564:145-60 [PubMed]

Johnston D, Wu SMS (1995) Foundations of Cellular Neurophysiology with simulations and illustrations by Richard Gray Foundations of Cellular Neurophysiology

Johnston D, Hoffman DA, Colbert CM, Magee JC (1999) Regulation of back-propagating action potentials in hippocampal neurons. Curr Opin Neurobiol 9:288-92 [PubMed]

Jones SW (2003) Calcium channels: unanswered questions. J Bioenerg Biomembr 35:461-75

Jung HY, Mickus T, Spruston N (1997) Prolonged sodium channel inactivation contributes to dendritic action potential attenuation in hippocampal pyramidal neurons. J Neurosci 17:6639-46 [PubMed]

Kang J, Huguenard JR, Prince DA (1996) Development of BK channels in neocortical pyramidal neurons. J Neurophysiol 76:188-98 [Journal] [PubMed]

Kim HG, Connors BW (1993) Apical dendrites of the neocortex: correlation between sodium- and calcium-dependent spiking and pyramidal cell morphology. J Neurosci 13:5301-11 [PubMed]

Kuriscak E, Trojan S, Wunsch Z (2002) Model of spike propagation reliability along the myelinated axon corrupted by axonal intrinsic noise sources. Physiol Res 51:205-15

Larkum ME, Zhu JJ (2002) Signaling of layer 1 and whisker-evoked Ca2+ and Na+ action potentials in distal and terminal dendrites of rat neocortical pyramidal neurons in vitro and in vivo. J Neurosci 22:6991-7005 [PubMed]

Larkum ME, Zhu JJ, Sakmann B (1999) A new cellular mechanism for coupling inputs arriving at different cortical layers. Nature 398:338-41 [PubMed]

Larkum ME, Zhu JJ, Sakmann B (2001) Dendritic mechanisms underlying the coupling of the dendritic with the axonal action potential initiation zone of adult rat layer 5 pyramidal neurons. J Physiol 533:447-66 [PubMed]

Luscher C, Streit J, Lipp P, Luscher HR (1994) Action potential propagation through embryonic dorsal root ganglion cells in culture. II. Decrease of conduction reliability during repetitive stimulation. J Neurophysiol 72:634-43 [Journal] [PubMed]

Mainen ZF, Sejnowski TJ (1995) Reliability of spike timing in neocortical neurons. Science 268:1503-6 [PubMed]

Mainen ZF, Sejnowski TJ (1996) Influence of dendritic structure on firing pattern in model neocortical neurons. Nature 382:363-6 [Journal] [PubMed]

   [2 reconstructed morphologies on NeuroMorpho.Org]
   Pyramidal Neuron Deep, Superficial; Aspiny, Stellate (Mainen and Sejnowski 1996) [Model]

Mainen ZF, Sejnowski TJ (1998) Chapter 5 Modeling Active Dendritic Processes in Pyramidal Cells Methods in Neuronal Modeling: From Ions to Networks :171-210

Manwani A, Koch C (1999) Detecting and estimating signals in noisy cable structures, II: information theoretical analysis. Neural Comput 11:1831-73 [PubMed]

Migliore M, Hoffman DA, Magee JC, Johnston D (1999) Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons. J Comput Neurosci 7:5-15 [Journal] [PubMed]

   CA1 pyramidal neuron (Migliore et al 1999) [Model]

Press WH, Teukolsky SA, Vellerling WT, Flannery BP (1992) Numerical Recipes In C: The Art Of Scientific Computing

Rudolph M, Destexhe A (2003) A fast-conducting, stochastic integrative mode for neocortical neurons in vivo. J Neurosci 23:2466-76 [PubMed]

Schaefer AT, Larkum ME, Sakmann B, Roth A (2003) Coincidence detection in pyramidal neurons is tuned by their dendritic branching pattern. J Neurophysiol 89:3143-54 [Journal] [PubMed]

   Pyramidal neuron coincidence detection tuned by dendritic branching pattern (Schaefer et al 2003) [Model]

Schneidman E, Freedman B, Segev I (1998) Ion channel stochasticity may be critical in determining the reliability and precision of spike timing. Neural Comput 10:1679-703 [PubMed]

Skaugen E, Walloe L (1979) Firing behaviour in a stochastic nerve membrane model based upon the Hodgkin-Huxley equations. Acta Physiol Scand 107:343-63 [PubMed]

Spruston N, Schiller Y, Stuart G, Sakmann B (1995) Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites. Science 268:297-300 [PubMed]

Steinmetz PN, Manwani A, Koch C, London M, Segev I (2001) Subthreshold voltage noise due to channel fluctuations in active neuronal membranes. J Comput Neurosci 9:133-48 [Journal] [PubMed]

Steriade M, Nunez A, Amzica F (1993) 1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components. J Neurosci 13:3252-65 [PubMed]

Stuart G, Spruston N, Sakmann B, Hausser M (1997) Action potential initiation and backpropagation in neurons of the mammalian CNS. Trends Neurosci 20:125-31 [PubMed]

van Rossum MC, O'Brien BJ, Smith RG (2003) Effects of noise on the spike timing precision of retinal ganglion cells. J Neurophysiol 89:2406-19 [PubMed]

Vetter P, Roth A, Hausser M (2001) Propagation of action potentials in dendrites depends on dendritic morphology. J Neurophysiol 85:926-37 [Journal] [PubMed]

   [13 reconstructed morphologies on NeuroMorpho.Org]
   Dendritica (Vetter et al 2001) [Model]

Waters J, Helmchen F (2004) Boosting of action potential backpropagation by neocortical network activity in vivo. J Neurosci 24:11127-36

Waters J, Larkum M, Sakmann B, Helmchen F (2003) Supralinear Ca2+ influx into dendritic tufts of layer 2-3 neocortical pyramidal neurons in vitro and in vivo. J Neurosci 23:8558-67 [PubMed]

Waters J, Schaefer A, Sakmann B (2005) Backpropagating action potentials in neurones: measurement, mechanisms and potential functions. Prog Biophys Mol Biol 87:145-70 [PubMed]

White JA, Klink R, Alonso A, Kay AR (1998) Noise from voltage-gated ion channels may influence neuronal dynamics in the entorhinal cortex. J Neurophysiol 80:262-9 [Journal] [PubMed]

White JA, Rubinstein JT, Kay AR (2000) Channel noise in neurons. Trends Neurosci 23:131-7 [PubMed]

Williams SR (2004) Spatial compartmentalization and functional impact of conductance in pyramidal neurons. Nat Neurosci 7:961-7 [PubMed]

Zhu JJ (2000) Maturation of layer 5 neocortical pyramidal neurons: amplifying salient layer 1 and layer 4 inputs by Ca2+ action potentials in adult rat tuft dendrites. J Physiol 526 Pt 3:571-87 [PubMed]

Cannon RC, O`Donnell C, Nolan MF (2010) Stochastic ion channel gating in dendritic neurons: morphology dependence and probabilistic synaptic activation of dendritic spikes. PLoS Comput Biol [Journal] [PubMed]

   Stochastic ion channels and neuronal morphology (Cannon et al. 2010) [Model]

Carnevale NT, Morse TM (1996-2009) Research reports that have used NEURON Web published citations at the NEURON website [Journal]

Dudman JT, Nolan MF (2009) Stochastically gating ion channels enable patterned spike firing through activity-dependent modulation of spike probability. PLoS Comput Biol 5:e1000290 [Journal] [PubMed]

(56 refs)