"... the preBotzinger complex...
we present and analyze a
mathematical model demonstrating an unconventional mechanism
of rhythm generation in which glutamatergic synapses and the
short-term depression of excitatory transmission play key rhythmogenic
Recurrent synaptic excitation triggers postsynaptic Ca2+-
activated nonspecific cation current (ICAN) to initiate a network-wide
Robust depolarization due to ICAN also causes voltage-dependent
spike inactivation, which diminishes recurrent excitation and
thus attenuates postsynaptic Ca2+ accumulation.
Rubin JE, Hayes JA, Mendenhall JL, Del Negro CA (2009) Calcium-activated nonspecific cation current and synaptic depression promote network-dependent burst oscillations. Proc Natl Acad Sci U S A 106:2939-44 [PubMed]