Hippocampus CA1: Temporal sensitivity of signaling pathways underlying LTP (Kim et al. 2010)

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Accession:125733
Temporal sensitivity of signaling pathways underlying L-LTP. Single compartment, deterministic model of calcium and dopamine activated pathways, leading to CaMKII and PKA activation. Experimental verification of model prediction.
Reference:
1 . Kim M, Huang T, Abel T, Blackwell KT (2010) Temporal Sensitivity of Protein Kinase A Activation in Late-Phase Long Term Potentiation PLoS Comput Biol 6(2):e1000691
Model Information (Click on a link to find other models with that property)
Model Type: Synapse;
Brain Region(s)/Organism:
Cell Type(s): Hippocampus CA1 pyramidal cell;
Channel(s):
Gap Junctions:
Receptor(s): Dopaminergic Receptor;
Gene(s):
Transmitter(s): Dopamine;
Simulation Environment: XPP;
Model Concept(s): Long-term Synaptic Plasticity; Signaling pathways;
Implementer(s): Blackwell, Avrama [avrama at gmu.edu];
Search NeuronDB for information about:  Hippocampus CA1 pyramidal cell; Dopaminergic Receptor; Dopamine;
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