Computer model of clonazepam`s effect in thalamic slice (Lytton 1997)

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Accession:12631
Demonstration of the effect of a minor pharmacological synaptic change at the network level. Clonazepam, a benzodiazepine, enhances inhibition but is paradoxically useful for certain types of seizures. This simulation shows how inhibition of inhibitory cells (the RE cells) produces this counter-intuitive effect.
Reference:
1 . Lytton WW (1997) Computer model of clonazepam's effect in thalamic slice. Neuroreport 8:3339-43 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell;
Channel(s): I Na,t; I T low threshold; I K; I CAN;
Gap Junctions:
Receptor(s): GabaA; Gaba;
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Bursting; Therapeutics; Epilepsy; Calcium dynamics;
Implementer(s): Lytton, William [billl at neurosim.downstate.edu];
Search NeuronDB for information about:  Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell; GabaA; Gaba; I Na,t; I T low threshold; I K; I CAN; Gaba;
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lytton97b
README
AMPA.mod
calciumpump_destexhe.mod *
GABAA.mod
GABAB1.mod
GABALOW.mod
HH_traub.mod *
IAHP_destexhe.mod
ICAN_destexhe.mod
ICAN_voltdep.mod
Ih_old.mod *
IT_wang.mod
IT2_huguenard.mod
NMDA.mod
passiv.mod *
pregen.mod *
presyn.mod *
pulse.mod
rand.mod
bg.inc *
boxes.hoc
ctl.dat
ctlnew.dat
czp.dat
czpnew.dat
declist.hoc *
decvec.hoc *
default.hoc *
disp.hoc
Fig3.gif
Fig4.gif
geom.hoc
grvec.hoc
init.hoc
labels.hoc
local.hoc
mod_func.c
mosinit.hoc
network.hoc
neurrep8
nrnoc.hoc
params.hoc
presyn.inc *
queue.inc *
run.hoc
show.hoc
simctrl.hoc *
sns.inc *
snsarr.inc
snscode.hoc
snsgr.hoc
snshead.inc *
synq.inc *
xtmp
                            
NEURON{ POINT_PROCESS NMDA
  RANGE B 
}

PARAMETER {
  mg    = 1.    (mM)            : external magnesium concentration
  Cdur	= 1.	(ms)		: transmitter duration (rising phase)
  Alpha	= 4.	(/ms mM)	: forward (binding) rate
  Beta	= 0.0067 (/ms)		: backward (unbinding) rate 1/150
  Erev	= 0.	(mV)		: reversal potential
  Deadtime = 1	(ms)		: mimimum time between release events
  GMAX	= 1     (S/cm2)         : maximum conductance
  DELAY = 0                     : axonal delay
}

ASSIGNED { B }
INCLUDE "sns.inc"
: BREAKPOINT MUST GO AFTER INCLUDE
BREAKPOINT {
  rates(v)
  g = g * B
  i = i * B
}
PROCEDURE rates(v(mV)) {
  TABLE B
  DEPEND mg
  FROM -100 TO 80 WITH 180
  B = 1 / (1 + exp(0.062 (/mV) * -v) * (mg / 3.57 (mM)))
}

:* >>>> Utility defaults <<<<  

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