Computer model of clonazepam`s effect in thalamic slice (Lytton 1997)

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Accession:12631
Demonstration of the effect of a minor pharmacological synaptic change at the network level. Clonazepam, a benzodiazepine, enhances inhibition but is paradoxically useful for certain types of seizures. This simulation shows how inhibition of inhibitory cells (the RE cells) produces this counter-intuitive effect.
Reference:
1 . Lytton WW (1997) Computer model of clonazepam's effect in thalamic slice. Neuroreport 8:3339-43 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell;
Channel(s): I Na,t; I T low threshold; I K; I CAN;
Gap Junctions:
Receptor(s): GabaA; Gaba;
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Bursting; Therapeutics; Epilepsy; Calcium dynamics;
Implementer(s): Lytton, William [billl at neurosim.downstate.edu];
Search NeuronDB for information about:  Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell; GabaA; Gaba; I Na,t; I T low threshold; I K; I CAN; Gaba;
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lytton97b
README
AMPA.mod
calciumpump_destexhe.mod *
GABAA.mod
GABAB1.mod
GABALOW.mod
HH_traub.mod *
IAHP_destexhe.mod
ICAN_destexhe.mod
ICAN_voltdep.mod
Ih_old.mod *
IT_wang.mod
IT2_huguenard.mod
NMDA.mod
passiv.mod *
pregen.mod *
presyn.mod *
pulse.mod
rand.mod
bg.inc *
boxes.hoc
ctl.dat
ctlnew.dat
czp.dat
czpnew.dat
declist.hoc *
decvec.hoc *
default.hoc *
disp.hoc
Fig3.gif
Fig4.gif
geom.hoc
grvec.hoc
init.hoc
labels.hoc
local.hoc
mod_func.c
mosinit.hoc
network.hoc
neurrep8
nrnoc.hoc
params.hoc
presyn.inc *
queue.inc *
run.hoc
show.hoc
simctrl.hoc *
sns.inc *
snsarr.inc
snscode.hoc
snsgr.hoc
snshead.inc *
synq.inc *
xtmp
                            
: $Id: pulse.mod,v 1.1 1998/07/21 13:54:10 billl Exp $
COMMENT
ENDCOMMENT

INDEPENDENT {t FROM 0 TO 1 WITH 1 (ms)}

NEURON {
  POINT_PROCESS PULSE
  NONSPECIFIC_CURRENT i
  RANGE amp, dur
}
 
INCLUDE "snsarr.inc"  : array management routines

UNITS {
  (nA) = (nanoamp)
  (mV) = (millivolt)
  (umho) = (micromho)
  (mM) = (milli/liter)
}

PARAMETER {
  dur	= 0	(ms)            : duration
  amp   = 0     (nA)            : amplitude
  Cdur  = 0                     : not used
  Deadtime = 0	(ms)		: mimimum time between release events, not used
  GMAX = 1	(umho)		: not used
  DELAY = 0     (ms)
}

ASSIGNED {
  i 		(nA)
  dt
}

INITIAL {
  i = 0
  if (nsyn > 0) {
    initq()   
  } 
}

BREAKPOINT {
  if (nsyn>0) { : do not try accessing a queue that hasn't been allocated
  VERBATIM 
  static int ii,who;
  static QueU *pqueu;
  static SynS *ppst;

  pqueu = (QueU *)((unsigned long) queu);

  while (t >= pqueu[(int)begsyn].time) { /*  somebody spiked delay time ago */
    i = -amp;
    popqh1(dur);		/* next (also add Cdur to value on the queu) */
  }

  while (t >= pqueu[(int)endsyn].time) { /*  somebody needs to be turned off */
    i = 0;
    popqh2();  /* next */
  }
  ENDVERBATIM
}
}

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