Computer model of clonazepam`s effect in thalamic slice (Lytton 1997)

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Accession:12631
Demonstration of the effect of a minor pharmacological synaptic change at the network level. Clonazepam, a benzodiazepine, enhances inhibition but is paradoxically useful for certain types of seizures. This simulation shows how inhibition of inhibitory cells (the RE cells) produces this counter-intuitive effect.
Reference:
1 . Lytton WW (1997) Computer model of clonazepam's effect in thalamic slice. Neuroreport 8:3339-43 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Realistic Network;
Brain Region(s)/Organism: Thalamus;
Cell Type(s): Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell;
Channel(s): I Na,t; I T low threshold; I K; I CAN;
Gap Junctions:
Receptor(s): GabaA; Gaba;
Gene(s):
Transmitter(s): Gaba;
Simulation Environment: NEURON;
Model Concept(s): Activity Patterns; Bursting; Therapeutics; Epilepsy; Calcium dynamics;
Implementer(s): Lytton, William [billl at neurosim.downstate.edu];
Search NeuronDB for information about:  Thalamus geniculate nucleus (lateral) principal neuron; Thalamus reticular nucleus cell; GabaA; Gaba; I Na,t; I T low threshold; I K; I CAN; Gaba;
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lytton97b
README
AMPA.mod
calciumpump_destexhe.mod *
GABAA.mod
GABAB1.mod
GABALOW.mod
HH_traub.mod *
IAHP_destexhe.mod
ICAN_destexhe.mod
ICAN_voltdep.mod
Ih_old.mod *
IT_wang.mod
IT2_huguenard.mod
NMDA.mod
passiv.mod *
pregen.mod *
presyn.mod *
pulse.mod
rand.mod
bg.inc *
boxes.hoc
ctl.dat
ctlnew.dat
czp.dat
czpnew.dat
declist.hoc *
decvec.hoc *
default.hoc *
disp.hoc
Fig3.gif
Fig4.gif
geom.hoc
grvec.hoc
init.hoc
labels.hoc
local.hoc
mod_func.c
mosinit.hoc
network.hoc
neurrep8
nrnoc.hoc
params.hoc
presyn.inc *
queue.inc *
run.hoc
show.hoc
simctrl.hoc *
sns.inc *
snsarr.inc
snscode.hoc
snsgr.hoc
snshead.inc *
synq.inc *
xtmp
                            
// $Id: simctrl.hoc,v 1.14 2000/11/27 21:59:33 billl Exp $
// Graphic routines for neuremacs simulation control

proc sim_panel () {
  xpanel(simname)
        xvarlabel(output_file)
	xbutton("Init", "stdinit()")
	xbutton("Init & Run", "run()")
	xbutton("Stop", "stoprun=1")
	xbutton("Continue till Tstop", "continueRun(tstop)")
	xvalue("Continue till", "runStopAt", 1, "{continueRun(runStopAt) stoprun=1}", 1, 1)
	xvalue("Continue for", "runStopIn", 1, "{continueRun(t + runStopIn) stoprun=1}", 1,1)
	xbutton("Single Step", "steprun()")
	xvalue("Tstop", "tstop", 1, "tstop_changed()", 0, 1)
	graphmenu()
	sim_menu_bar()
	misc_menu_bar()
  xpanel()
}

proc misc_menu_bar() {
  xmenu("Miscellaneous")
    xbutton("Label Graphs", "labelgrs()")
    xbutton("Label With String", "labelwith()")
    xbutton("Label Panel", "labelpanel()")
	xbutton("Parameterized Function", "load_template(\"FunctionFitter\") makefitter()")
  xmenu()
}

proc sim_menu_bar() {
  xmenu("Simulation Control")
    xbutton("File Vers", "elisp(\"sim-current-files\")")
    xbutton("File Status...", "elisp(\"sim-rcs-status\")")
    xbutton("Sim Status", "elisp(\"sim-portrait\")")
    xbutton("Load Current Files", "elisp(\"sim-load-sim\")")
    xbutton("Load Templates", "elisp(\"sim-load-templates\")") 
    xbutton("Load File...", "elisp(\"sim-load-file\")") 
    xbutton("Save Sim...", "elisp(\"sim-save-sim\")")
    xbutton("Set File Vers...", "elisp(\"sim-set-file-ver\")")
    xbutton("Read Current Vers From Index", "elisp(\"sim-read-index-file\")")
    xbutton("Read Last Saved Vers", "elisp(\"sim-read-recent-versions\")")
    xbutton("Output to sim buffer", "elisp(\"sim-direct-output\")")
  xmenu()
}

proc labelpanel() {
  xpanel(simname,1)
	xvarlabel(output_file)
  xpanel()
}

proc labels () {
  labelwith($s1)
  labelgrs()
}

proc labelgrs () { local i, j, cnt
  for j=0,n_graph_lists-1 {
    cnt = graphList[j].count() - 1
    for i=0,cnt labelgr(graphList[j].object(i))
  }
}

proc labelwith () { local i, j, cnt
  temp_string_ = user_string_  // save the old one
  if (numarg() == 1) { /* interactive mode */  
    user_string_ = $s1
  } else {
    string_dialog("write what?", user_string_)
  }
  for j=0,n_graph_lists-1 {
    cnt = graphList[j].count() - 1
    for i=0,cnt {
      graphList[j].object(i).color(0)
      graphList[j].object(i).label(0.5,0.9,temp_string_)
      graphList[j].object(i).color(1)
      graphList[j].object(i).label(0.5,0.9,user_string_)
    }
  }
}

proc labelgr () { local i
  $o1.color(0)  // white overwrite
  for (i=0;i<10;i=i+1) { // erase every possible runnum for this date
    sprint(temp_string_,"%s %d%d",datestr,i,i)
    $o1.label(0.1,0.7,temp_string_) }
  $o1.color(1) // back to basic black
  sprint(temp_string_,"%s %02d",datestr,runnum)
  $o1.label(0.1,0.7,temp_string_)
}


Lytton WW (1997) Computer model of clonazepam's effect in thalamic slice. Neuroreport 8:3339-43[PubMed]

References and models cited by this paper

References and models that cite this paper

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   Thalamic quiescence of spike and wave seizures (Lytton et al 1997) [Model]

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