A simplified cerebellar Purkinje neuron (the PPR model) (Brown et al. 2011)

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Accession:126637
These models were implemented in NEURON by Sherry-Ann Brown in the laboratory of Leslie M. Loew. The files reproduce Figures 2c-f from Brown et al, 2011 "Virtual NEURON: a Strategy For Merged Biochemical and Electrophysiological Modeling".
Reference:
1 . Brown SA, Moraru II, Schaff JC, Loew LM (2011) Virtual NEURON: a strategy for merged biochemical and electrophysiological modeling. J Comput Neurosci 31(2):385-400 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Dendrite;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum Purkinje cell;
Channel(s): I Na,p; I p,q; I A; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s):
Simulation Environment: NEURON;
Model Concept(s): Dendritic Action Potentials; Simplified Models; Active Dendrites; Influence of Dendritic Geometry; Detailed Neuronal Models; Intrinsic plasticity; Methods; Synaptic Integration;
Implementer(s): Brown, Sherry-Ann [sabrown at student.uchc.edu];
Search NeuronDB for information about:  Cerebellum Purkinje cell; I Na,p; I p,q; I A; I K; I M; I K,Ca; I Sodium; I Calcium; I Potassium;
objectvar save_window_, rvp_
objectvar scene_vector_[6]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
{pwman_place(0,0,0)}

//Begin PointProcessManager
{
load_file("pointman.hoc")
}
{
soma ocbox_ = new PointProcessManager(0)
}
{object_push(ocbox_)}
{
mt.select("IClamp") i = mt.selected()
ms[i] = new MechanismStandard("IClamp")
ms[i].set("del", 20, 0)
ms[i].set("dur", 400, 0)
ms[i].set("amp", 2, 0)
mt.select("IClamp") i = mt.selected() maction(i)
hoc_ac_ = 0
sec.sec move() d1.flip_to(0)
}
{object_pop() doNotify()}
{
ocbox_ = ocbox_.v1
ocbox_.map("PointProcessManager", 454, 683, 212.598, 245.48)
}
objref ocbox_
//End PointProcessManager

{
save_window_ = new Graph(0)
save_window_.size(0,500,-80,40)
scene_vector_[3] = save_window_
{save_window_.view(0, -80, 500, 120, 791, 0, 298.772, 200.069)}
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
save_window_.addexpr("v(.5)", 1, 1, 0.8, 0.9, 2)
}
{
save_window_ = new PlotShape(0)
save_window_.size(-28.0594,249.694,-157.016,122.239)
save_window_.variable("v")
scene_vector_[4] = save_window_
{save_window_.view(-28.0594, -157.016, 277.753, 279.255, 83, 672, 198.992, 200.069)}
fast_flush_list.append(save_window_)
save_window_.save_name("fast_flush_list.")
}
{
xpanel("RunControl", 0)
v_init = -67.8
xvalue("Init","v_init", 1,"stdinit()", 1, 1 )
xbutton("Init & Run","run()")
xbutton("Stop","stoprun=1")
runStopAt = 500
xvalue("Continue til","runStopAt", 1,"{continuerun(runStopAt) stoprun=1}", 1, 1 )
runStopIn = 1
xvalue("Continue for","runStopIn", 1,"{continuerun(t + runStopIn) stoprun=1}", 1, 1 )
xbutton("Single Step","steprun()")
t = 500.025
xvalue("t","t", 2 )
tstop = 500
xvalue("Tstop","tstop", 1,"tstop_changed()", 0, 1 )
dt = 0.00025
xvalue("dt","dt", 1,"setdt()", 0, 1 )
steps_per_ms = 40
xvalue("Points plotted/ms","steps_per_ms", 1,"setdt()", 0, 1 )
xcheckbox("Quiet",&stdrun_quiet,"")
realtime = 764
xvalue("Real Time","realtime", 0,"", 0, 1 )
xpanel(81,107)
}
{
save_window_ = new Graph(0)
save_window_.size(0,500,-80,40)
scene_vector_[5] = save_window_
{save_window_.view(0, -80, 500, 120, 791, 422, 298.772, 200.069)}
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
save_window_.addexpr("SpinyDendrite[133].v( 0.5 )", 1, 1, 0.8, 0.9, 2)
}
{
save_window_ = new Graph(0)
save_window_.size(0,500,-80,40)
scene_vector_[5] = save_window_
{save_window_.view(0, -80, 500, 120, 791, 422, 298.772, 200.069)}
graphList[0].append(save_window_)
save_window_.save_name("graphList[0].")
save_window_.addexpr("Spine.v( 0.5 )", 1, 1, 0.8, 0.9, 2)
}
objectvar scene_vector_[1]
{doNotify()}

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