The model demonstrates that CA1 pyramidal neurons support rebound spikes mediated by hyperpolarization-activated inward current (Ih), and normally masked by A-type potassium channels (KA). Partial KA reduction confined to one or few branches of the apical tuft may be sufficient to elicit a local spike following a train of synaptic inhibition. These data suggest that the plastic regulation of KA can provide a dynamic switch to unmask post-inhibitory spiking in CA1 pyramidal neurons, further increasing the signal processing power of the CA1 synaptic microcircuitry.
Ascoli GA, Gasparini S, Medinilla V, Migliore M (2010) Local Control of Post-Inhibitory Rebound Spiking in CA1 Pyramidal Neuron Dendrites J.Neurosci. 30(18):6434-42 [PubMed]