CA3 pyramidal neuron (Safiulina et al. 2010)

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Accession:126814
In this review some of the recent work carried out in our laboratory concerning the functional role of GABAergic signalling at immature mossy fibres (MF)-CA3 principal cell synapses has been highlighted. To compare the relative strength of CA3 pyramidal cell output in relation to their MF glutamatergic or GABAergic inputs in postnatal development, a realistic model was constructed taking into account the different biophysical properties of these synapses.
Reference:
1 . Safiulina VF, Caiati MD, Sivakumaran S, Bisson G, Migliore M, Cherubini E (2010) Control of GABA release at mossy fiber-CA3 connections in the developing hippocampus Front Synaptic Neurosci 2:1 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal cell;
Channel(s): I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Bursting; Temporal Pattern Generation; Active Dendrites; Detailed Neuronal Models; Action Potentials; Synaptic Integration; Spike Frequency Adaptation;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal cell; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I Calcium; Gaba; Glutamate;
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develop
readme.html
cacumm.mod *
cagk.mod *
cal2.mod *
can2.mod *
cat.mod *
h.mod *
KahpM95.mod *
kaprox.mod *
kdrca1.mod *
km.mod *
na3n.mod *
develop.hoc
develop.ses
ec-cell1zr-loop.hoc
fixnseg.hoc *
gabaAt20.jpg
gabaAt40.jpg
geo-cell1zr.hoc *
gluAt20.jpg
gluAt40.jpg
mosinit.hoc
                            
COMMENT
	calcium accumulation into a volume of area*depth next to the
	membrane with a decay (time constant tau) to resting level
	given by the global calcium variable cai0_ca_ion
	Modified to include a resting current (irest) and peak value
	(cmax)
	i is a dummy current needed to force a BREAKPOINT
ENDCOMMENT

NEURON {
	SUFFIX cacum
	USEION ca READ ica WRITE cai
	NONSPECIFIC_CURRENT i
	RANGE depth, tau, cai0, cmax
}

UNITS {
	(mM) = (milli/liter)
	(mA) = (milliamp)
	F = (faraday) (coulombs)
}

PARAMETER {
	depth = 0.1 (um)	: assume volume = area*depth
	irest = 0  (mA/cm2)		: to be initialized in hoc	
	tau = 100 (ms)
	cai0 = 50e-6 (mM)	: Requires explicit use in INITIAL
			: block for it to take precedence over cai0_ca_ion
			: Do not forget to initialize in hoc if different
			: from this default.
}

ASSIGNED {
	ica (mA/cm2)
	cmax
	i  	 (mA/cm2)
}

STATE {
	cai (mM)
}

INITIAL {
	cai = cai0
	irest = ica
	cmax=cai
}

BREAKPOINT {
	SOLVE integrate METHOD derivimplicit
	if (cai>cmax) {cmax=cai}
	i=0
}

DERIVATIVE integrate {
	cai' = (irest-ica)/depth/F/2 * (1e4) + (cai0 - cai)/tau
}

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