CA3 pyramidal neuron (Safiulina et al. 2010)

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Accession:126814
In this review some of the recent work carried out in our laboratory concerning the functional role of GABAergic signalling at immature mossy fibres (MF)-CA3 principal cell synapses has been highlighted. To compare the relative strength of CA3 pyramidal cell output in relation to their MF glutamatergic or GABAergic inputs in postnatal development, a realistic model was constructed taking into account the different biophysical properties of these synapses.
Reference:
1 . Safiulina VF, Caiati MD, Sivakumaran S, Bisson G, Migliore M, Cherubini E (2010) Control of GABA Release at Mossy Fiber-CA3 Connections in the Developing Hippocampus. Front Synaptic Neurosci 2:1 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Synapse; Dendrite;
Brain Region(s)/Organism: Hippocampus;
Cell Type(s): Hippocampus CA3 pyramidal GLU cell;
Channel(s): I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I Calcium;
Gap Junctions:
Receptor(s):
Gene(s):
Transmitter(s): Gaba; Glutamate;
Simulation Environment: NEURON;
Model Concept(s): Action Potential Initiation; Dendritic Action Potentials; Bursting; Temporal Pattern Generation; Active Dendrites; Detailed Neuronal Models; Action Potentials; Synaptic Integration; Spike Frequency Adaptation;
Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu];
Search NeuronDB for information about:  Hippocampus CA3 pyramidal GLU cell; I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I M; I h; I Calcium; Gaba; Glutamate;
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readme.html
cacumm.mod *
cagk.mod *
cal2.mod *
can2.mod *
cat.mod *
h.mod *
KahpM95.mod *
kaprox.mod *
kdrca1.mod *
km.mod *
na3n.mod *
develop.hoc
develop.ses
ec-cell1zr-loop.hoc
fixnseg.hoc *
gabaAt20.jpg
gabaAt40.jpg
geo-cell1zr.hoc *
gluAt20.jpg
gluAt40.jpg
mosinit.hoc
                            
TITLE T-calcium channel
: T-type calcium channel


UNITS {
	(mA) = (milliamp)
	(mV) = (millivolt)
	(molar) = (1/liter)
	(mM) = (millimolar)

	FARADAY = 96520 (coul)
	R = 8.3134 (joule/degC)
	KTOMV = .0853 (mV/degC)
}

PARAMETER {
	v (mV)
	celsius = 25	(degC)
	gcatbar=.003 (mho/cm2)
	cai = 50.e-6 (mM)
	cao = 2 (mM)
	q10 = 5
	mmin=0.2
	hmin=10
	a0h =0.015
	zetah = 3.5
	vhalfh = -75
	gmh=0.6	
	a0m =0.04
	zetam = 2
	vhalfm = -28
	gmm=0.1	
}


NEURON {
	SUFFIX cat
	USEION ca READ cai,cao WRITE ica
        RANGE gcatbar, ica, gcat
        GLOBAL hinf,minf,mtau,htau
}

STATE {
	m h 
}

ASSIGNED {
	ica (mA/cm2)
        gcat (mho/cm2)
	hinf
	htau
	minf
	mtau
}

INITIAL {
	rates(v)
	m = minf
	h = hinf
}

BREAKPOINT {
	SOLVE states METHOD cnexp
	gcat = gcatbar*m*m*h
	ica = gcat*ghk(v,cai,cao)

}

DERIVATIVE states {	: exact when v held constant
	rates(v)
	m' = (minf - m)/mtau
	h' = (hinf - h)/htau
}


FUNCTION ghk(v(mV), ci(mM), co(mM)) (mV) {
        LOCAL nu,f

        f = KTF(celsius)/2
        nu = v/f
        ghk=-f*(1. - (ci/co)*exp(nu))*efun(nu)
}

FUNCTION KTF(celsius (DegC)) (mV) {
        KTF = ((25./293.15)*(celsius + 273.15))
}


FUNCTION efun(z) {
	if (fabs(z) < 1e-4) {
		efun = 1 - z/2
	}else{
		efun = z/(exp(z) - 1)
	}
}

FUNCTION alph(v(mV)) {
  alph = exp(0.0378*zetah*(v-vhalfh)) 
}

FUNCTION beth(v(mV)) {
  beth = exp(0.0378*zetah*gmh*(v-vhalfh)) 
}

FUNCTION alpmt(v(mV)) {
  alpmt = exp(0.0378*zetam*(v-vhalfm)) 
}

FUNCTION betmt(v(mV)) {
  betmt = exp(0.0378*zetam*gmm*(v-vhalfm)) 
}

PROCEDURE rates(v (mV)) { :callable from hoc
	LOCAL a,b, qt
        qt=q10^((celsius-25)/10)

	a = 0.2*(-1.0*v+19.26)/(exp((-1.0*v+19.26)/10.0)-1.0)
	b = 0.009*exp(-v/22.03)
	minf = a/(a+b)
	mtau = betmt(v)/(qt*a0m*(1+alpmt(v)))
	if (mtau<mmin) {mtau=mmin}

	a = 1.e-6*exp(-v/16.26)
	b = 1/(exp((-v+29.79)/10.)+1.)
	hinf = a/(a+b)
	htau = beth(v)/(a0h*(1+alph(v)))
	if (htau<hmin) {htau=hmin}
}


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