Alcohol excites Cerebellar Golgi Cells by inhibiting the Na+/K+ ATPase (Botta et al.2010)

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Patch-clamp in cerebellar slices and computer modeling show that ethanol excites Golgi cells by inhibiting the Na+/K+ ATPase. In particular, voltage-clamp recordings of Na+/K+ ATPase currents indicated that ethanol partially inhibits this pump and this effect could be mimicked by low concentrations of the Na+/K+ ATPase blocker ouabain. The partial inhibition of Na+/K+ ATPase in a computer model of the Golgi cell reproduced these experimental findings that established a novel mechanism of action of ethanol on neural excitability.
1 . Botta P, de Souza FM, Sangrey T, De Schutter E, Valenzuela CF (2010) Alcohol excites cerebellar Golgi cells by inhibiting the Na+/K+ ATPase. Neuropsychopharmacology 35:1984-96 [PubMed]
Model Information (Click on a link to find other models with that property)
Model Type: Neuron or other electrically excitable cell; Electrogenic pump;
Brain Region(s)/Organism: Cerebellum;
Cell Type(s): Cerebellum golgi cell;
Channel(s): Na/K pump;
Gap Junctions:
Gene(s): HCN1;
Simulation Environment: NEURON;
Model Concept(s): Detailed Neuronal Models; Markov-type model; Alcohol Use Disorder;
Implementer(s): Simoes-de-Souza, Fabio [fabio.souza at];
Search NeuronDB for information about:  Na/K pump;
sessions * *
objectvar save_window_, rvp_
objectvar scene_vector_[5]
objectvar ocbox_, ocbox_list_, scene_, scene_list_
{ocbox_list_ = new List()  scene_list_ = new List()}
save_window_ = new Graph(0)
scene_vector_[3] = save_window_
{save_window_.view(-100, 50, 5100, 57, 0, 621, 557.76, 319.36)}
save_window_.label(0.5, 0, "time (ms)", 2, 1, 1, 0, 1)
save_window_.label(0, 0.5, "[ca] (nM)", 2, 1, 0, 1, 1)
save_window_.addexpr("Golgi[0].soma.cai( 0.5 )*1e6", 1, 1, 0.8, 0.9, 2)
save_window_.addexpr("Golgi[0].soma.ca2i( 0.5 )*1e6", 4, 1, 0.8, 0.9, 2)
objectvar scene_vector_[1]

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